PMID- 18067188
OWN - NLM
STAT- MEDLINE
DCOM- 20080508
LR  - 20080304
IS  - 1531-8257 (Electronic)
IS  - 0885-3185 (Linking)
VI  - 23
IP  - 3
DP  - 2008 Feb 15
TI  - Multicenter study on deep brain stimulation in Parkinson's disease: an 
      independent assessment of reported adverse events at 4 years.
PG  - 416-21
AB  - Ongoing adverse events (AEs) at 4-years postsurgery in 69 patients with advanced 
      Parkinson's disease (PD) who received deep brain stimulation (DBS) of the 
      subthalamic nucleus (STN) (n = 49) or the internal globus pallidus (GPi) (n = 
      20), in the framework of a subset of eight centers of a multicenter study, were 
      analyzed by an independent ad hoc committee. At baseline, the patients' age, sex, 
      disease duration, and clinical condition were virtually identical, as was the 
      duration of follow-up. There were 64 AEs reported in 53% of STN DBS patients and 
      eight AEs reported in 35% of GPi DBS patients. Most of the AEs were not deemed 
      severe and were reported to be present "both with and without stimulation." The 
      majority of the AEs affected patients' cognitive, psychiatric and behavioral 
      status, as well as speech, gait, and balance, and most of these AEs occurred in 
      STN DBS patients. When comparing patients who exhibited AEs with those who did 
      not, it was found that in the STN DBS group, the patients with AEs had a longer 
      disease duration, as well as more gait disorders and psychiatric disturbances at 
      baseline.
CI  - 2007 Movement Disorder Society
FAU - Hariz, Marwan I
AU  - Hariz MI
AD  - Sobell Department of Motor Neuroscience and Movement Disorders, Institute of 
      Neurology, Queen Square, London, United Kingdom. m.hariz@ion.ucl.ac.uk
FAU - Rehncrona, Stig
AU  - Rehncrona S
FAU - Quinn, Niall P
AU  - Quinn NP
FAU - Speelman, Johannes D
AU  - Speelman JD
FAU - Wensing, Carin
AU  - Wensing C
CN  - Multicentre Advanced Parkinson's Disease Deep Brain Stimulation Group
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Deep Brain Stimulation/*adverse effects/*methods
MH  - Female
MH  - Gait Disorders, Neurologic/etiology
MH  - Globus Pallidus/physiology/radiation effects
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Mental Disorders/etiology
MH  - Middle Aged
MH  - Neurologic Examination
MH  - Parkinson Disease/*therapy
MH  - Subthalamic Nucleus/physiology/radiation effects
FIR - Agid, Y
IR  - Agid Y
FIR - Welter, M
IR  - Welter M
FIR - Houeto, J L
IR  - Houeto JL
FIR - Cornu, P
IR  - Cornu P
FIR - Dormont, D
IR  - Dormont D
FIR - Albanese, A
IR  - Albanese A
FIR - Bentivoglio, A R
IR  - Bentivoglio AR
FIR - Contarino, F
IR  - Contarino F
FIR - Romito, L
IR  - Romito L
FIR - Scerrati, M
IR  - Scerrati M
FIR - Kulisevsky, J
IR  - Kulisevsky J
FIR - Gironell, A
IR  - Gironell A
FIR - Lang, A E
IR  - Lang AE
FIR - Lozano, A
IR  - Lozano A
FIR - Moro, E
IR  - Moro E
FIR - Obeso, J A
IR  - Obeso JA
FIR - Rodriguez-Oroz, M
IR  - Rodriguez-Oroz M
FIR - Guridi, J
IR  - Guridi J
FIR - Pollak, P
IR  - Pollak P
FIR - Benabid, A L
IR  - Benabid AL
FIR - Fraix, V
IR  - Fraix V
FIR - Krack, P
IR  - Krack P
FIR - Seigneuret, E
IR  - Seigneuret E
FIR - Charbardes
IR  - Charbardes
FIR - Rehncrona, S
IR  - Rehncrona S
FIR - Tornqvist, A L
IR  - Tornqvist AL
FIR - Ekberg, R
IR  - Ekberg R
FIR - Volkmann, J
IR  - Volkmann J
FIR - Schnitzler, A
IR  - Schnitzler A
FIR - Timmerman, L
IR  - Timmerman L
FIR - Wojtecki, L
IR  - Wojtecki L
EDAT- 2007/12/11 09:00
MHDA- 2008/05/09 09:00
CRDT- 2007/12/11 09:00
PHST- 2007/12/11 09:00 [pubmed]
PHST- 2008/05/09 09:00 [medline]
PHST- 2007/12/11 09:00 [entrez]
AID - 10.1002/mds.21888 [doi]
PST - ppublish
SO  - Mov Disord. 2008 Feb 15;23(3):416-21. doi: 10.1002/mds.21888.