PMID- 18067446
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20161018
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 45
IP  - 12
DP  - 2007
TI  - The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and 
      psychiatric diseases.
PG  - 1590-606
AB  - Hyperhomocysteinemia (HHcy) is related to central nervous system diseases. 
      Epidemiological studies show a positive, dose-dependent relationship between 
      plasma total homocysteine (tHcy) concentration and neurodegenerative disease 
      risk. tHcy is a marker of B-vitamin (folate, B(12), B(6)) status. 
      Hypomethylation, caused by low B-vitamin status and HHcy, is linked to key 
      pathomechanisms of dementia; B-vitamin supplementation could potentially reduce 
      neurological damage. In retrospective studies, the association between tHcy and 
      cognition is impressive; there is also evidence that tHcy-lowering treatment 
      could be effective in primary and secondary stroke prevention. Increased tHcy and 
      low serum folate occur in patients with Parkinson's disease, especially those 
      receiving L-dopa. There is also an association between HHcy and multiple 
      sclerosis, and between B-vitamin status and depression. Studies also confirm a 
      causal role for tHcy in epilepsy, and certain anti-epileptics enhance HHcy. 
      B-vitamin status should be optimized by ensuring sufficient intake in patients 
      with neuropsychiatric diseases. HHcy occurs commonly in the elderly and can 
      contribute to age-related neurodegeneration. Treatment with folic acid, B(12) and 
      B(6) lowers tHcy. For secondary and primary prevention from several 
      neuropsychiatric disorders, it seems prudent to actively identify deficient 
      subjects and ensure sufficient vitamin intake.
FAU - Obeid, Rima
AU  - Obeid R
AD  - Department of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, 
      University Hospital of Saarland, Homburg/Saar, Germany.
FAU - McCaddon, Andrew
AU  - McCaddon A
FAU - Herrmann, Wolfgang
AU  - Herrmann W
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
SB  - IM
MH  - Central Nervous System Diseases/*complications
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Mental Disorders/*complications
MH  - Vitamin B Deficiency/*complications
RF  - 172
EDAT- 2007/12/11 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/12/11 09:00
PHST- 2007/12/11 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/12/11 09:00 [entrez]
AID - 10.1515/CCLM.2007.356 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2007;45(12):1590-606. doi: 10.1515/CCLM.2007.356.