PMID- 18067447
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20210803
IS  - 1434-6621 (Print)
IS  - 1434-6621 (Linking)
VI  - 45
IP  - 12
DP  - 2007
TI  - The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) 
      deficiencies in osteoporosis: a systematic review.
PG  - 1621-32
AB  - Hyperhomocysteinemia (HHCY) has been suggested as a new risk factor for 
      osteoporosis. Recent epidemiological, clinical and experimental studies provide a 
      growing body of data, which is reviewed in this article. Epidemiological and 
      (randomized) clinical trials suggest that HHCY increases fracture risk, but has 
      minor effects on bone mineral density. Measurement of biochemical bone turnover 
      markers indicates a shift of bone metabolism towards bone resorption. Animal 
      studies confirm these observations showing a reduced bone quality and stimulation 
      of bone resorption in hyperhomocysteinemic animals. Homocysteine (HCY) has been 
      found to accumulate in bone by collagen binding. Cell culture studies demonstrate 
      that high HCY levels stimulate osteoclasts but not osteoblasts, indicating again 
      a shift of bone metabolism towards bone resorption. Regarding B-vitamins, only a 
      few in vivo studies with equivocal results have been published. However, two 
      large cell culture studies confirm the results obtained with exogenous HCY 
      administration. In addition, HHCY seems to have adverse affects on extracellular 
      bone matrix by disturbing collagen crosslinking. In conclusion, existing data 
      suggest that HHCY (and possibly B-vitamin deficiencies) adversely affects bone 
      quality by a stimulation of bone resorption and disturbance of collagen 
      crosslinking.
FAU - Herrmann, Markus
AU  - Herrmann M
AD  - ANZAC Research Institute, University of Sydney, Sydney NSW, Australia. 
      markusherr@aol.com
FAU - Peter Schmidt, Johannes
AU  - Peter Schmidt J
FAU - Umanskaya, Natalia
AU  - Umanskaya N
FAU - Wagner, Alexandra
AU  - Wagner A
FAU - Taban-Shomal, Omid
AU  - Taban-Shomal O
FAU - Widmann, Thomas
AU  - Widmann T
FAU - Colaianni, Graziana
AU  - Colaianni G
FAU - Wildemann, Britt
AU  - Wildemann B
FAU - Herrmann, Wolfgang
AU  - Herrmann W
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 8059-24-3 (Vitamin B 6)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
EIN - Clin Chem Lab Med. 2020 Nov 23;59(2):455. PMID: 33554504
MH  - Animals
MH  - Bone Density
MH  - Folic Acid Deficiency/*complications
MH  - Fractures, Bone/complications
MH  - Humans
MH  - Hyperhomocysteinemia/*complications
MH  - Osteoporosis/*complications
MH  - Vitamin B 12/metabolism
MH  - Vitamin B 6/metabolism
MH  - Vitamin B Deficiency/*complications
RF  - 93
EDAT- 2007/12/11 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/12/11 09:00
PHST- 2007/12/11 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/12/11 09:00 [entrez]
AID - 10.1515/CCLM.2007.362 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2007;45(12):1621-32. doi: 10.1515/CCLM.2007.362.