PMID- 18068614
OWN - NLM
STAT- MEDLINE
DCOM- 20080117
LR  - 20220318
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 13
IP  - 10
DP  - 2007 Dec
TI  - Depression is a major determinant of quality of life in patients with chronic 
      systolic heart failure in general practice.
PG  - 818-24
AB  - BACKGROUND: Quality of life (QoL) is severely restricted in patients with chronic 
      heart failure (CHF). Patients frequently suffer from depressive comorbidity. It 
      is not clear, to what extent sociodemographic variables, heart failure severity, 
      somatic comorbidities and depression determine QoL of patients with CHF in 
      primary care. METHODS AND RESULTS: In a cross-sectional analysis, 167 patients, 
      68.2 +/- 10.1 years old, 68.9% male, New York Heart Association (NYHA) functional 
      class II-IV, Left ventricular ejection fraction (LVEF) < or = 40%, were recruited 
      in their general practitioner's practices. Heart failure severity was assessed 
      with echocardiography and N-terminal brain natriuretic peptide (NT-proBNP); 
      multimorbidity was assessed with the Cumulative Illness Rating Scale (CIRS-G). 
      QoL was measured with the Short Form 36 Health Survey (SF-36) and depression with 
      the depression module of the Patient Health Questionnaire (PHQ-9). Significant 
      correlations with all SF-36 subscales were only found for the CIRS-G (r = -0.18 
      to -0.36; P < .05) and the PHQ-9 (r = -0.26 to -0.75; P < .01). In multivariate 
      forward regression analyses, the PHQ-9 summary score explained the most part of 
      QoL variance in all of the SF-36 subscales (r2 = 0.17-0.56). LVEF and NT-proBNP 
      did not have significant influence on QoL. CONCLUSIONS: Depression is a major 
      determinant of quality of life in patients with chronic systolic heart failure, 
      whereas somatic measures of heart failure severity such as NT-proBNP and LVEF do 
      not contribute to quality of life. Correct diagnosis and treatment of depressive 
      comorbidity in heart failure patients is essential.
FAU - Muller-Tasch, Thomas
AU  - Muller-Tasch T
AD  - Department of Psychosomatic and General Internal Medicine, University of 
      Heidelberg, Germany.
FAU - Peters-Klimm, Frank
AU  - Peters-Klimm F
FAU - Schellberg, Dieter
AU  - Schellberg D
FAU - Holzapfel, Nicole
AU  - Holzapfel N
FAU - Barth, Annika
AU  - Barth A
FAU - Junger, Jana
AU  - Junger J
FAU - Szecsenyi, Joachim
AU  - Szecsenyi J
FAU - Herzog, Wolfgang
AU  - Herzog W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Depression/complications/*psychology
MH  - *Family Practice
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure, Systolic/complications/physiopathology/*psychology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - *Quality of Life
MH  - Stroke Volume/physiology
MH  - Surveys and Questionnaires
EDAT- 2007/12/11 09:00
MHDA- 2008/01/18 09:00
CRDT- 2007/12/11 09:00
PHST- 2007/03/05 00:00 [received]
PHST- 2007/07/11 00:00 [revised]
PHST- 2007/07/23 00:00 [accepted]
PHST- 2007/12/11 09:00 [pubmed]
PHST- 2008/01/18 09:00 [medline]
PHST- 2007/12/11 09:00 [entrez]
AID - S1071-9164(07)01004-4 [pii]
AID - 10.1016/j.cardfail.2007.07.008 [doi]
PST - ppublish
SO  - J Card Fail. 2007 Dec;13(10):818-24. doi: 10.1016/j.cardfail.2007.07.008.