PMID- 18068998
OWN - NLM
STAT- MEDLINE
DCOM- 20080325
LR  - 20220409
IS  - 1096-0023 (Electronic)
IS  - 1043-4666 (Linking)
VI  - 41
IP  - 1
DP  - 2008 Jan
TI  - Positive and negative signaling components involved in TNFalpha-induced NF-kappaB 
      activation.
PG  - 1-8
AB  - Tumor Necrosis Factor alpha (TNFalpha) is a pro-inflammatory cytokine that plays 
      important roles in different biological processes, including the induction of 
      other cytokines. One of the most important downstream signaling targets activated 
      by TNFalpha is the NF-kappaB transcription factor, which has been identified to 
      be involved in inflammatory, anti-apoptotic, and immune responses. Stimulation of 
      cells with TNFalpha triggers activation of NF-kappaB through various signaling 
      molecules, including TRAF2, RIP, MAP3K, and the IKK complex. Recently, numerous 
      studies have been performed to explore the detailed mechanism by which NF-kappaB 
      is activated upon TNFalpha stimulation. Current understanding of this pathway has 
      been focused on the identification of signaling components, the role of 
      post-translational modification and the sub-cellular translocation of those 
      components. Additionally, more negative regulators in the TNF-IKK pathway are 
      emerging.
FAU - Li, Hongxiu
AU  - Li H
AD  - Department of Molecular and Cellular Oncology, University of Texas, M.D. Anderson 
      Cancer Center, 1515 Holcombe Boulevard, Unit 108, Houston, TX 77030, USA.
FAU - Lin, Xin
AU  - Lin X
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (I-kappa B Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (TNF Receptor-Associated Factor 2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.1 (Receptor-Interacting Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
SB  - IM
MH  - Animals
MH  - Humans
MH  - I-kappa B Proteins/genetics/metabolism
MH  - MAP Kinase Kinase Kinases/genetics/metabolism
MH  - NF-kappa B/genetics/*metabolism
MH  - Protein Transport/physiology
MH  - Receptor-Interacting Protein Serine-Threonine Kinases/genetics/metabolism
MH  - Signal Transduction/*physiology
MH  - TNF Receptor-Associated Factor 2/genetics/metabolism
MH  - Tumor Necrosis Factor-alpha/genetics/*metabolism
RF  - 75
EDAT- 2007/12/11 09:00
MHDA- 2008/03/26 09:00
CRDT- 2007/12/11 09:00
PHST- 2007/09/06 00:00 [received]
PHST- 2007/09/28 00:00 [accepted]
PHST- 2007/12/11 09:00 [pubmed]
PHST- 2008/03/26 09:00 [medline]
PHST- 2007/12/11 09:00 [entrez]
AID - S1043-4666(07)00452-8 [pii]
AID - 10.1016/j.cyto.2007.09.016 [doi]
PST - ppublish
SO  - Cytokine. 2008 Jan;41(1):1-8. doi: 10.1016/j.cyto.2007.09.016.