PMID- 18070153
OWN - NLM
STAT- MEDLINE
DCOM- 20080328
LR  - 20081121
IS  - 1365-2222 (Electronic)
IS  - 0954-7894 (Linking)
VI  - 38
IP  - 2
DP  - 2008 Feb
TI  - Correlation between immune and neuronal parameters and stress perception in 
      allergic asthmatics.
PG  - 283-90
AB  - BACKGROUND: Asthma is a chronic disease defined by airway inflammation, increased 
      airway hyperresponsiveness and episodes of airway obstruction. Although there are 
      abundant clinical and experimental data showing that stress may worsen asthma, 
      the mechanisms linking stress to asthma are not well understood. By inducing a 
      pro-inflammatory cytokine milieu, stress might enhance airway inflammation in 
      bronchial asthma. We therefore investigated the correlation of stress perception 
      and the cytokine profile of circulating lymphocytes in humans. METHODS: Allergic 
      asthmatic patients and healthy controls were evaluated for perceived level of 
      stress, demographic and lung function data. Whole blood cells were obtained and 
      stimulated by mitogen to assess intracellular IL-4, IFN-gamma and TNF-alpha by 
      flow cytometry. Neurotrophins nerve growth factor (NGF) and brain-derived 
      neurotrophic factor (BDNF) were measured in serum. RESULTS: Asthmatic patients 
      showed significantly higher percentages of TNF-alpha-producing T cells than 
      healthy controls. Only in asthmatic patients was stress perception correlated 
      with percentages of TNF-alpha-producing T cells and serum BDNF levels, while 
      forced expiratory volume in 1 s (% predicted) was negatively correlated to BDNF. 
      CONCLUSION: The results of our study support the hypothesis that stress 
      deteriorates bronchial asthma by inducing a pro-inflammatory cytokine profile in 
      allergic asthmatics. Stress management might provide a supplement therapy of 
      allergic asthma.
FAU - Joachim, R A
AU  - Joachim RA
AD  - Department of Internal Medicine and Psychosomatics, Charite Center for Internal 
      Medicine and Dermatology, Charite-Universitaetsmedizin, Berlin, Germany. 
      ricarda.joachim@charite.de
FAU - Noga, O
AU  - Noga O
FAU - Sagach, V
AU  - Sagach V
FAU - Hanf, G
AU  - Hanf G
FAU - Fliege, H
AU  - Fliege H
FAU - Kocalevent, R D
AU  - Kocalevent RD
FAU - Peters, E M
AU  - Peters EM
FAU - Klapp, B F
AU  - Klapp BF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071207
PL  - England
TA  - Clin Exp Allergy
JT  - Clinical and experimental allergy : journal of the British Society for Allergy 
      and Clinical Immunology
JID - 8906443
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (Nerve Growth Factors)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Asthma/diagnosis/*immunology
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cytokines/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/blood
MH  - Nerve Growth Factors/*blood
MH  - Respiratory Hypersensitivity/diagnosis/*immunology
MH  - Stress, Physiological/*complications/diagnosis
MH  - T-Lymphocytes/immunology
EDAT- 2007/12/12 09:00
MHDA- 2008/03/29 09:00
CRDT- 2007/12/12 09:00
PHST- 2007/12/12 09:00 [pubmed]
PHST- 2008/03/29 09:00 [medline]
PHST- 2007/12/12 09:00 [entrez]
AID - CEA2899 [pii]
AID - 10.1111/j.1365-2222.2007.02899.x [doi]
PST - ppublish
SO  - Clin Exp Allergy. 2008 Feb;38(2):283-90. doi: 10.1111/j.1365-2222.2007.02899.x. 
      Epub 2007 Dec 7.