PMID- 18070229
OWN - NLM
STAT- MEDLINE
DCOM- 20080313
LR  - 20220408
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 63
IP  - 3
DP  - 2008 Mar
TI  - Assessing skin prick tests reliability in ECRHS-I.
PG  - 341-6
AB  - INTRODUCTION: Atopy, the clinical definition of an immunoglobulin E (IgE) 
      high-responder, can be documented either by the detection of IgE antibodies in 
      serum or by a positive skin prick test. Epidemiological studies use different 
      reaction sizes to define a skin test reaction as positive or negative. The aim of 
      the study was to identify the best cut-off level for skin prick tests. METHOD: 
      Using the data collected during the European Community Respiratory Health Survey 
      (ECHRS I) the association of serum allergen-specific IgE and skin prick tests 
      [Dermatophagoides pteronyssinus (Der p), cat, timothy grass and Cladosporium] 
      were assessed. RESULTS: The proportion of the 11 355 subjects (49.9% men), with 
      positive skin tests ranged from 10.4% (cut-off >5 mm) to 20.9% (cut-off >0 mm) 
      for Der p, 3.5-10.2% for cat, 9.3-16.6% for timothy grass and 0.2 and 2.3% for 
      Cladosporium. For identifying subjects with detectable specific IgE (>0.35 kU/l) 
      the most appropriate cut-off appeared to be over 0 mm for Der p, cat and timothy 
      grass (Youden Index over 0.81). However, the relationship between serum IgE and 
      skin prick test for Cladosporium was weak (Youden index under 0.56). CONCLUSION: 
      In epidemiological studies, a single method may be chosen to assess allergenic 
      sensitivity. A cut-off level of over 0 mm for skin prick tests was best at 
      identifying those with allergen-specific IgE.
FAU - Bousquet, P-J
AU  - Bousquet PJ
AD  - Respiratory Epidemiology and Public Health, Imperial College, London, UK.
FAU - Chatzi, L
AU  - Chatzi L
FAU - Jarvis, D
AU  - Jarvis D
FAU - Burney, P
AU  - Burney P
LA  - eng
GR  - 2 S07 RR05521-28/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20071207
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Animals
MH  - Cats
MH  - Cladosporium/immunology
MH  - Cohort Studies
MH  - Confidence Intervals
MH  - Europe
MH  - *Evaluation Studies as Topic
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*diagnosis/epidemiology
MH  - Immunoglobulin E/*immunology
MH  - Male
MH  - Multicenter Studies as Topic
MH  - Phleum/immunology
MH  - Probability
MH  - Registries
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Skin Tests/*methods
EDAT- 2007/12/12 09:00
MHDA- 2008/03/14 09:00
CRDT- 2007/12/12 09:00
PHST- 2007/12/12 09:00 [pubmed]
PHST- 2008/03/14 09:00 [medline]
PHST- 2007/12/12 09:00 [entrez]
AID - ALL1581 [pii]
AID - 10.1111/j.1398-9995.2007.01581.x [doi]
PST - ppublish
SO  - Allergy. 2008 Mar;63(3):341-6. doi: 10.1111/j.1398-9995.2007.01581.x. Epub 2007 
      Dec 7.