PMID- 18070608
OWN - NLM
STAT- MEDLINE
DCOM- 20080610
LR  - 20220408
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1783
IP  - 4
DP  - 2008 Apr
TI  - Function and redox state of mitochondrial localized cysteine-rich proteins 
      important in the assembly of cytochrome c oxidase.
PG  - 618-28
AB  - The cytochrome c oxidase (CcO) complex of the mitochondrial respiratory chain 
      exists within the mitochondrial inner membrane (IM). The biogenesis of the 
      complex is a multi-faceted process requiring multiple assembly factors that 
      function on both faces of the IM. Formation of the two copper centers of CcO 
      occurs within the intermembrane space (IMS) and is dependent on assembly factors 
      with critical cysteinyl thiolates. Two classes of assembly factors exist, one 
      group being soluble IMS proteins and the second class being proteins tethered to 
      the IM. A common motif in the soluble assembly factors is a duplicated Cx(9)C 
      sequence motif. Since mitochondrial respiration is a major source of reactive 
      oxygen species, control of the redox state of mitochondrial proteins is an 
      important process. This review documents the role of these cysteinyl CcO assembly 
      factors within the IMS and the necessity of redox control in their function.
FAU - Khalimonchuk, Oleh
AU  - Khalimonchuk O
AD  - University of Utah Health Sciences Center, Department of Medicine, Salt Lake 
      City, Utah 84132, USA.
FAU - Winge, Dennis R
AU  - Winge DR
LA  - eng
GR  - R37 ES003817/ES/NIEHS NIH HHS/United States
GR  - R37 ES003817-26/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20071109
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Mitochondrial Proteins)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - Cysteine/chemistry/*metabolism
MH  - Electron Transport Complex IV/*metabolism
MH  - Mitochondria/*metabolism
MH  - Mitochondrial Proteins/*metabolism
MH  - Oxidation-Reduction
PMC - PMC2374233
MID - NIHMS46970
EDAT- 2007/12/12 09:00
MHDA- 2008/06/11 09:00
PMCR- 2009/04/01
CRDT- 2007/12/12 09:00
PHST- 2007/09/18 00:00 [received]
PHST- 2007/10/22 00:00 [revised]
PHST- 2007/10/30 00:00 [accepted]
PHST- 2007/12/12 09:00 [pubmed]
PHST- 2008/06/11 09:00 [medline]
PHST- 2007/12/12 09:00 [entrez]
PHST- 2009/04/01 00:00 [pmc-release]
AID - S0167-4889(07)00265-0 [pii]
AID - 10.1016/j.bbamcr.2007.10.016 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 2008 Apr;1783(4):618-28. doi: 10.1016/j.bbamcr.2007.10.016. 
      Epub 2007 Nov 9.