PMID- 18074861
OWN - NLM
STAT- MEDLINE
DCOM- 20080122
LR  - 20071213
IS  - 1233-9687 (Print)
IS  - 1233-9687 (Linking)
VI  - 58
IP  - 3
DP  - 2007
TI  - Molecular cytogenetic analysis of chromosome aberrations in desmoid tumors.
PG  - 167-71
AB  - To date there are only few reports concerning chromosomal changes in desmoid 
      tumors. To extend the knowledge in this field we examined 19 samples from the 
      patients diagnosed with desmoid tumors. In the present study formalin-fixed and 
      paraffin-embedded desmoid tumors were analyzed using fluorescence in situ 
      hybridization (FISH) with a-satellite probes for chromosomes X, Y, 8 and 20. 
      Chromosomal abnormalities were found in 6 cases, both abdominal and 
      extra-abdominal tumors. FISH studies revealed one case of trisomy 8 and trisomy 
      20. In four patients we have identified monosomy 20. Our findings confirm earlier 
      reports concerning the diversity of chromosomal changes in desmoid tumors and 
      might suggest that both groups of abdominal and extra-abdominal tumors are 
      genuine neoplasms.
FAU - Mayer, Magdalena
AU  - Mayer M
AD  - Department of Medical Genetics, University of Medical Sciences in Poznan. 
      mkanik@amp.edu.pl
FAU - Kulig, Andrzej
AU  - Kulig A
FAU - Sygut, Jacek
AU  - Sygut J
FAU - Dziki, Adam
AU  - Dziki A
FAU - Simon, Dorota
AU  - Simon D
FAU - Latos-Bielenska, Anna
AU  - Latos-Bielenska A
FAU - Ferenc, Tomasz
AU  - Ferenc T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Pol J Pathol
JT  - Polish journal of pathology : official journal of the Polish Society of 
      Pathologists
JID - 9437432
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 20/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - Chromosomes, Human, X/genetics
MH  - Chromosomes, Human, Y/genetics
MH  - *Cytogenetic Analysis
MH  - Female
MH  - Fibromatosis, Aggressive/*genetics
MH  - Gene Dosage
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
EDAT- 2007/12/14 09:00
MHDA- 2008/01/23 09:00
CRDT- 2007/12/14 09:00
PHST- 2007/12/14 09:00 [pubmed]
PHST- 2008/01/23 09:00 [medline]
PHST- 2007/12/14 09:00 [entrez]
PST - ppublish
SO  - Pol J Pathol. 2007;58(3):167-71.