PMID- 18075285
OWN - NLM
STAT- MEDLINE
DCOM- 20080110
LR  - 20211020
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 30
IP  - 10
DP  - 2007 Nov
TI  - Physiological dose of lycopene suppressed oxidative stress and enhanced serum 
      levels of immunoglobulin M in patients with Type 2 diabetes mellitus: a possible 
      role in the prevention of long-term complications.
PG  - 833-8
AB  - OBJECTIVE: This study was undertaken to evaluate the antioxidant effects of 
      lycopene in physiological doses and its possible effects on the immune response 
      in patients with Type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS: A 
      total of 35 patients with T2DM of both sexes aged 54+/-9 yr were enrolled in a 
      double-blind placebo-controlled clinical trial conducted for 2 months. After a 
      2-week lycopene-free diet washout period, patients were allocated to either 
      lycopene supplementation group (10 mg/day) (no.=16) or placebo group (no.=19), 
      which were age- and sex matched. Patients were instructed to keep their diet and 
      physical activity as unchanged as possible. RESULTS: While dietary intake of 
      energy and body weight did not change, the ratio of serum total antioxidant 
      capacity (TAC) to malondialdehyde (MDA) increased significantly in the lycopene 
      group compared to the placebo group (p=0.007). Though a statistically significant 
      increase in serum concentrations of lycopene (p<0.001) was not accompanied by 
      enhanced delayed-type hypersensitivity response, a significant negative 
      correlation was found between serum levels of lycopene and immunoglobulin (Ig)G 
      (r=-0.338, p=0.008). Interestingly, variations of serum levels of lycopene 
      directly correlated with those of IgM (r=0.466, p=0.005). There was an 
      insignificant decrement in serum anti-oxidized LDL IgG levels in the lycopene 
      group. CONCLUSIONS: Lycopene, probably by increasing TAC and inhibiting MDA-LDL 
      formation, may attenuate T cell-dependent adaptive (pro-atherogenic) immune 
      response. Meanwhile, with enhancement of innate immunity and hence prevention of 
      ox-LDL uptake by macrophage and foam cell formation, lycopene may be effective in 
      prevention of long-term diabetic complications, notably cardiovascular disease.
FAU - Neyestani, T R
AU  - Neyestani TR
AD  - Laboratory of Nutrition Research, National Nutrition and Food Technology Research 
      Institute and Faculty of Nutritional Sciences and Food Technology, Shaheed 
      Beheshti, University of Medical Sciences, Tehran, Iran. tneyestani@nnftri.ac.ir
FAU - Shariatzadeh, N
AU  - Shariatzadeh N
FAU - Gharavi, A
AU  - Gharavi A
FAU - Kalayi, A
AU  - Kalayi A
FAU - Khalaji, N
AU  - Khalaji N
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Antioxidants)
RN  - 0 (Immunoglobulin M)
RN  - 36-88-4 (Carotenoids)
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - SB0N2N0WV6 (Lycopene)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antioxidants/*administration & dosage
MH  - Cardiovascular Diseases/metabolism/prevention & control
MH  - Carotenoids/*administration & dosage
MH  - Diabetes Complications/metabolism/*prevention & control
MH  - Diabetes Mellitus, Type 2/*drug therapy/immunology/metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin M/*blood
MH  - Lycopene
MH  - Male
MH  - Malondialdehyde/blood
MH  - Middle Aged
MH  - Oxidative Stress/*drug effects
EDAT- 2007/12/14 09:00
MHDA- 2008/01/11 09:00
CRDT- 2007/12/14 09:00
PHST- 2007/12/14 09:00 [pubmed]
PHST- 2008/01/11 09:00 [medline]
PHST- 2007/12/14 09:00 [entrez]
AID - 4233 [pii]
AID - 10.1007/BF03349224 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2007 Nov;30(10):833-8. doi: 10.1007/BF03349224.