PMID- 18075884
OWN - NLM
STAT- MEDLINE
DCOM- 20080319
LR  - 20071213
IS  - 1478-6419 (Print)
IS  - 1478-6419 (Linking)
VI  - 21
IP  - 14
DP  - 2007 Dec
TI  - In vitro antitumor activity of triterpenes from Ceriops tagal.
PG  - 1228-33
AB  - The embryo of Ceriops tagal was extracted with 95% ethanol at room temperature, 
      and four triterpenes (1-4) were separated from this extract. For the first time 
      these triterpenes were the separated from this plant. Compounds (1-4) were tested 
      in vitro for antitumor activity against three cell lines (human liver cancer cell 
      (H-7402), human B-lymphoblastoid cell (Raji), and human cervical carcinoma cell 
      (Hela)). Compounds 1 and 3 were effective to inhibit cell proliferation and 
      growth of H-7402 and Hela, the IC(50) of them on H-7402 were 14.42 microg mL(-1) 
      and 9.97 microg mL(-1), and the IC(50) of them on Hela were 11.84 microg mL(-1) 
      and 11.32 microg mL(-1). All compounds 1-4 were not effective to inhibit cell 
      proliferation and growth of Raji. The effects of compound 4 on inhibiting 
      proliferation and growth of these three cancer cells was also not obvious.
FAU - He, Lei
AU  - He L
AD  - Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of 
      Oceanology, Chinese Academic of Sciences, Guangzhou 510301, China.
FAU - Wang, You-Shao
AU  - Wang YS
FAU - Wang, Qing-Ji
AU  - Wang QJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nat Prod Res
JT  - Natural product research
JID - 101167924
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Plant Extracts)
RN  - 0 (Triterpenes)
SB  - IM
MH  - Antineoplastic Agents/chemistry/isolation & purification/*pharmacology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Drug Screening Assays, Antitumor
MH  - HeLa Cells
MH  - Humans
MH  - Molecular Structure
MH  - Plant Extracts/chemistry/isolation & purification/pharmacology
MH  - Plants, Medicinal/chemistry
MH  - Rhizophoraceae/*chemistry
MH  - Triterpenes/chemistry/isolation & purification/*pharmacology
EDAT- 2007/12/14 09:00
MHDA- 2008/03/20 09:00
CRDT- 2007/12/14 09:00
PHST- 2007/12/14 09:00 [pubmed]
PHST- 2008/03/20 09:00 [medline]
PHST- 2007/12/14 09:00 [entrez]
AID - 788432922 [pii]
AID - 10.1080/14786410701369516 [doi]
PST - ppublish
SO  - Nat Prod Res. 2007 Dec;21(14):1228-33. doi: 10.1080/14786410701369516.