PMID- 18076341
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20080509
IS  - 1744-7666 (Electronic)
IS  - 1465-6566 (Linking)
VI  - 9
IP  - 1
DP  - 2008 Jan
TI  - Economic evaluation of the use of enoxaparin in non-ST-elevation acute coronary 
      syndrome.
PG  - 95-105
AB  - This paper reviews the published literature on the costs and benefits of 
      low-molecular-weight heparins (LMWHs) compared with unfractionated heparin (UFH), 
      in patients with non-ST-segment-elevation acute coronary syndrome (NSTE-ACS). 
      Although LMWH has superior efficacy to UFH in NSTE-ACS, it must also provide 
      cost-effectiveness or net-cost savings before its wide use can be approved by 
      healthcare payers. The drug-acquisition costs of LMWH are higher than those of 
      UFH, but economic analyses should also consider the initial medical resource 
      consumption and the downstream costs associated with failed treatment and 
      subsequent care. Based on published economic analyses, the incremental drug costs 
      of LMWH compared with UFH are compensated for by savings in medical-resource 
      costs secondary to reducing ischemic events in NSTE-ACS patients.
FAU - Nutescu, Edith A
AU  - Nutescu EA
AD  - Antithrombosis Center, The University of Illinois at Chicago, College of 
      Pharmacy, Department of Pharmacy Practice, 833 S. Wood Street, MC 886, Room 164, 
      Chicago, Illinois 60612-7230, USA. enutescu@uic.edu
FAU - Steinmetz Pater, Karen
AU  - Steinmetz Pater K
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Expert Opin Pharmacother
JT  - Expert opinion on pharmacotherapy
JID - 100897346
RN  - 0 (Anticoagulants)
RN  - 0 (Enoxaparin)
SB  - IM
MH  - Anticoagulants/*economics/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Cost-Benefit Analysis
MH  - Enoxaparin/*economics/*therapeutic use
MH  - Health Care Costs
MH  - Humans
MH  - Myocardial Ischemia/*drug therapy
RF  - 51
EDAT- 2007/12/14 09:00
MHDA- 2008/02/15 09:00
CRDT- 2007/12/14 09:00
PHST- 2007/12/14 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2007/12/14 09:00 [entrez]
AID - 10.1517/14656566.9.1.95 [doi]
PST - ppublish
SO  - Expert Opin Pharmacother. 2008 Jan;9(1):95-105. doi: 10.1517/14656566.9.1.95.