PMID- 18077099
OWN - NLM
STAT- MEDLINE
DCOM- 20080506
LR  - 20211020
IS  - 0306-4530 (Print)
IS  - 0306-4530 (Linking)
VI  - 33
IP  - 2
DP  - 2008 Feb
TI  - Prenatal stress does not alter innate novelty-seeking behavioral traits, but 
      differentially affects individual differences in neuroendocrine stress 
      responsivity.
PG  - 162-77
AB  - Exposure to stress during prenatal or early postnatal life can dramatically 
      impact adult behavior and neuroendocrine function. We recently began to 
      selectively breed Sprague-Dawley rats for high (high responder, HR) and low (low 
      responder, LR) novelty-seeking behavior, a trait that predicts a variety of 
      differences in emotional reactivity, including differences in neuroendocrine 
      stress response, fear- and anxiety-like behavior, aggression, and propensity to 
      self-administer drugs of abuse. We evaluated genetic-early environment 
      interactions by exposing HR- and LR-bred animals to prenatal stress (PS) from 
      pregnancy day 3-20, hypothesizing that PS exposure would differentially impact HR 
      versus LR behavior and neuroendocrine reactivity. We evaluated novelty-induced 
      locomotion, anxiety-like behavior, and corticosterone stress response in weanling 
      (25-day-old) and adult HR-LR stressed and control males. Exposure to PS did not 
      alter HR-LR differences in locomotion, but did impact anxiety-like behavior, 
      specifically in LR animals. Surprisingly, LR animals exposed to PS exhibited less 
      anxiety than LR controls. HR rats were not affected by PS, with both stress and 
      control groups showing low levels of anxiety. PS differentially impacted 
      neuroendocrine stress reactivity in young versus adult HR-LR animals, leading to 
      an exaggerated corticosterone response in LR pups compared to LR controls, while 
      HRs pups were unaffected. In contrast, exposure to PS produced an exaggerated 
      stress response in HR adults, compared to HR controls, while LR animals were not 
      significantly affected. These findings highlight how genetic predisposition may 
      shape individual's response to early life stressors, and furthermore, show that a 
      history of early life stress may differentially impact an organism at different 
      points in life. Future work will explore neural mechanisms which underlie the 
      different behavioral and neuroendocrine consequences of PS in HR versus LR 
      animals.
FAU - Clinton, Sarah
AU  - Clinton S
AD  - Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina 
      Pitcher Place, Ann Arbor, MI 48109-0720, USA. clintons@umich.edu
FAU - Miller, Sue
AU  - Miller S
FAU - Watson, Stanley J
AU  - Watson SJ
FAU - Akil, Huda
AU  - Akil H
LA  - eng
GR  - P01 DA021633/DA/NIDA NIH HHS/United States
GR  - P01 MH042251/MH/NIMH NIH HHS/United States
GR  - R01 DA12286/DA/NIDA NIH HHS/United States
GR  - R01 DA013386/DA/NIDA NIH HHS/United States
GR  - R01 DA013386-05/DA/NIDA NIH HHS/United States
GR  - P01 MH042251-20/MH/NIMH NIH HHS/United States
GR  - P01 MH42251/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Validation Study
PL  - England
TA  - Psychoneuroendocrinology
JT  - Psychoneuroendocrinology
JID - 7612148
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Receptors, Mineralocorticoid)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Age Factors
MH  - Analysis of Variance
MH  - Animals
MH  - Anxiety/blood/etiology/genetics
MH  - Corticosterone/*blood
MH  - Exploratory Behavior/*physiology
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Hippocampus/*metabolism
MH  - Hypothalamo-Hypophyseal System/physiology
MH  - Male
MH  - Motor Activity/physiology
MH  - Phenotype
MH  - Pituitary-Adrenal System/physiology
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Rats, Sprague-Dawley
MH  - Receptors, Glucocorticoid/genetics/*metabolism
MH  - Receptors, Mineralocorticoid/genetics/metabolism
MH  - Selection, Genetic
MH  - Species Specificity
MH  - Statistics, Nonparametric
MH  - Stress, Psychological/*blood/complications/physiopathology
PMC - PMC2430412
MID - NIHMS40106
EDAT- 2007/12/14 09:00
MHDA- 2008/05/07 09:00
PMCR- 2009/02/01
CRDT- 2007/12/14 09:00
PHST- 2007/04/16 00:00 [received]
PHST- 2007/10/24 00:00 [revised]
PHST- 2007/10/31 00:00 [accepted]
PHST- 2007/12/14 09:00 [pubmed]
PHST- 2008/05/07 09:00 [medline]
PHST- 2007/12/14 09:00 [entrez]
PHST- 2009/02/01 00:00 [pmc-release]
AID - S0306-4530(07)00247-8 [pii]
AID - 10.1016/j.psyneuen.2007.10.012 [doi]
PST - ppublish
SO  - Psychoneuroendocrinology. 2008 Feb;33(2):162-77. doi: 
      10.1016/j.psyneuen.2007.10.012.