PMID- 18077569
OWN - NLM
STAT- MEDLINE
DCOM- 20080421
LR  - 20220311
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1122
DP  - 2007 Dec
TI  - Brain-derived neurotrophic factor in neuronal survival and behavior-related 
      plasticity.
PG  - 130-43
AB  - Neurotrophins are critical to the development and maintenance of the mammalian 
      central nervous system. Among them is brain-derived neurotrophic factor (BDNF), 
      whose synthesis and release is targeted by activation of glutamate receptors. 
      Perturbation of this process probably underlies neurodegenerative and psychiatric 
      disorders. A naturally occurring variation in humans, in the form of a common 
      single-nucleotide polymorphism in the pro region of the polypeptide at codon 66 
      (Val66-->Met), affects processing of the pro-BDNF polypeptide and its 
      activation-dependent release. This variant is associated with differences in the 
      volume of the hippocampal formation and with anxiety and depression-related 
      phenotypes. Convergent findings supporting a role for BDNF in alterations to 
      hippocampal structure and behavior are found in a "humanized" BDNF transgenic 
      mouse. Also, recent human genetic studies have supported a role of BDNF signaling 
      in addictive behaviors by allele-, genotype-, and haplotype-based association of 
      the TrkB gene, which encodes the cognate receptor for BDNF, with alcohol 
      dependence. A better understanding of the influence of BDNF-mediated pathways in 
      cell survival and plasticity will aid in developing new approaches to restoring 
      normal function in disease states.
FAU - Lipsky, Robert H
AU  - Lipsky RH
AD  - Section of Molecular Genetics, Laboratory of Neurogenetics, National Institute on 
      Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20814, 
      USA.
FAU - Marini, Ann M
AU  - Marini AM
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - *Behavioral Symptoms/genetics/pathology/physiopathology
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cell Survival/physiology
MH  - Humans
MH  - Memory/physiology
MH  - Mutation
MH  - Neuronal Plasticity/genetics/*physiology
MH  - Neurons/pathology/*physiology
RF  - 83
EDAT- 2007/12/14 09:00
MHDA- 2008/04/22 09:00
CRDT- 2007/12/14 09:00
PHST- 2007/12/14 09:00 [pubmed]
PHST- 2008/04/22 09:00 [medline]
PHST- 2007/12/14 09:00 [entrez]
AID - 1122/1/130 [pii]
AID - 10.1196/annals.1403.009 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Dec;1122:130-43. doi: 10.1196/annals.1403.009.