PMID- 18081629
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20071217
IS  - 1323-1316 (Print)
IS  - 1323-1316 (Linking)
VI  - 61
IP  - 6
DP  - 2007 Dec
TI  - Effectiveness of comprehensive supports for schizophrenic women during pregnancy 
      and puerperium: preliminary study.
PG  - 665-71
AB  - The risks of deteriorated psychiatric symptoms/daily life functioning should be 
      warned of in schizophrenic women during pregnancy and puerperium. The purpose of 
      the present paper was to prospectively monitor mental status and functioning of 
      pregnant women with schizophrenia, and investigate the effects of various 
      supports. Subjects were 20 schizophrenic women who visited a clinic providing 
      care and support for pregnant women with psychiatric diseases, consisting of 12 
      patients with psychotic deterioration (deterioration group) and eight remitted 
      stable patients (stable group). Psychiatric assessments were performed using 
      Positive and Negative Syndrome Scale (PANSS) and Global Assessment of Functioning 
      (GAF) at three time-points: at the first examination, after fixed prescription 
      during pregnancy, and after delivery. The types/doses of drugs and other 
      non-drug-related supports (13 items) were recorded during the study period. 
      Although a higher total PANSS score at the first examination (P = 0.004) and 
      lower GAF scores at the first examination and even after fixed prescription (P = 
      0.0003) were observed in the deterioration group, those after delivery finally 
      caught up with the levels in the stable group. Doses of antipsychotic drugs were 
      gradually increased in the deterioration group although no significant 
      differences in chlorpromazine equivalent doses were found between the two groups 
      after fixed prescription. There was a positive correlation between the number of 
      non-drug-related supports and amelioration score in PANSS (r(s) = 0.553, P = 
      0.012). These findings suggest that comprehensive intervention is a requisite in 
      pregnant schizophrenic women, especially with psychotic deterioration, and that 
      non-drug-related supports may also contribute to maintenance of good and stable 
      mental status in these patients.
FAU - Nishizawa, Osamu
AU  - Nishizawa O
AD  - Department of Neuropsychiatry, University of the Ryukyus, Faculty of Medicine, 
      Nishihara, Okinawa, Japan. o.zawanishi@nifty.ne.jp
FAU - Sakumoto, Kaoru
AU  - Sakumoto K
FAU - Hiramatsu, Ken-Ichi
AU  - Hiramatsu K
FAU - Kondo, Tsuyoshi
AU  - Kondo T
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Psychiatry Clin Neurosci
JT  - Psychiatry and clinical neurosciences
JID - 9513551
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/adverse effects/therapeutic use
MH  - Child
MH  - Child Care
MH  - Data Interpretation, Statistical
MH  - Female
MH  - Humans
MH  - Postpartum Period/*psychology
MH  - Pregnancy
MH  - Pregnancy Complications/psychology/*therapy
MH  - Pregnancy Trimesters
MH  - Prospective Studies
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/drug therapy/*therapy
MH  - *Social Support
EDAT- 2007/12/18 09:00
MHDA- 2008/02/15 09:00
CRDT- 2007/12/18 09:00
PHST- 2007/12/18 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2007/12/18 09:00 [entrez]
AID - PCN1721 [pii]
AID - 10.1111/j.1440-1819.2007.01721.x [doi]
PST - ppublish
SO  - Psychiatry Clin Neurosci. 2007 Dec;61(6):665-71. doi: 
      10.1111/j.1440-1819.2007.01721.x.