PMID- 18081645
OWN - NLM
STAT- MEDLINE
DCOM- 20080411
LR  - 20071217
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 26 Suppl 2
DP  - 2007 Dec
TI  - Review article: The laryngological manifestations of reflux disease; why the 
      scepticism?
PG  - 17-24
LID - 10.1111/j.1365-2036.2007.03474.x [doi]
AB  - BACKGROUND: Despite increasing clinical and experimental evidence of its 
      existence, otolaryngological manifestations of reflux disease remain 
      controversial, concerning diagnosis as well as treatment. AIM: Proper 
      understanding of laryngopharyngeal reflux disease (LPRD). METHOD: Review of 
      literature. RESULTS: Scepticism concerning LPRD is based upon differences between 
      gastro-oesophageal reflux disease and LPRD; lack of specificity and sensitivity 
      of diagnostic tests to confirm LPRD; non-specificity of laryngological symptoms, 
      which are difficult to distinguish from other causes of upper respiratory tract 
      inflammation; non-specificity of laryngological signs in laryngoscopy, with high 
      intra- and inter-observer variability in evaluation; diagnosis of LPRD is 
      essentially only based on a combination of diagnostic signs and symptoms, which 
      cannot be attributed to other pathology; slow, or sometimes lack of, response of 
      LPRD symptoms to proton pump inhibitor (PPI) medication and lack of evidence 
      concerning efficacy of PPIs in placebo-controlled trials. CONCLUSIONS: LPRD 
      remains a diagnosis by exclusion and resolution of symptoms following 4-month 
      trial of 40 mg PPI twice daily is, for all practical purposes, considered proof 
      of the initial diagnosis. However, non-response does not exclude LPRD as PPIs 
      have no influence on noxious non-acid components of the refluxate.
FAU - Mahieu, H F
AU  - Mahieu HF
AD  - Department of Otorhinolaryngology, Meander Medical Centre, Amersfoort, The 
      Netherlands. hf.mahieu@meandermc.nl
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Esophageal pH Monitoring
MH  - Gastroesophageal Reflux/*diagnosis/drug therapy/etiology
MH  - Humans
MH  - Laryngeal Diseases/*diagnosis
MH  - Laryngoscopy/methods
MH  - Proton Pump Inhibitors/*therapeutic use
RF  - 87
EDAT- 2008/01/08 09:00
MHDA- 2008/04/12 09:00
CRDT- 2008/01/08 09:00
PHST- 2008/01/08 09:00 [pubmed]
PHST- 2008/04/12 09:00 [medline]
PHST- 2008/01/08 09:00 [entrez]
AID - APT3474 [pii]
AID - 10.1111/j.1365-2036.2007.03474.x [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2007 Dec;26 Suppl 2:17-24. doi: 
      10.1111/j.1365-2036.2007.03474.x.