PMID- 18081795
OWN - NLM
STAT- MEDLINE
DCOM- 20090107
LR  - 20181030
IS  - 1525-1438 (Electronic)
IS  - 1048-891X (Linking)
VI  - 18
IP  - 5
DP  - 2008 Sep-Oct
TI  - The outcome of patients with stage I endometrial cancer involving the lower 
      uterine segment.
PG  - 1079-83
AB  - The objective of this study was to evaluate whether lower uterine segment 
      involvement (LUSI) correlates with recurrence and survival in women with stage I 
      endometrial adenocarcinoma and whether it is associated with poor prognostic 
      histopathologic features. Three hundred seventy-five consecutive patients with 
      endometrial carcinoma stage I compromised the study population. The patients were 
      divided into two groups according to the presence of LUSI with endometrial 
      carcinoma. The two groups were compared with regard to prognostic factors and 
      outcome measures by using the Pearson chi(2) test, log-rank test, and Cox 
      proportional hazards model. LUSI was present in 89 (24%) patients with stage I 
      endometrial carcinoma. LUSI was significantly associated with grade 3 tumor (P = 
      0.022), deep myometrial invasion (P < 0.0001), and the presence of capillary 
      space-like involvement (CSLI) (P = 0.003). Kaplan-Meier survival curves 
      demonstrated that patients with LUSI had a lower recurrence-free survival 
      (log-rank test; P = 0.009) and a worse overall survival (log-rank test; P = 
      0.0008). In the Cox proportional hazards model, only a trend toward higher 
      recurrence rate (HR = 2.4, 95% CI 0.7, 8.2; P = 0.16) and a trend toward poorer 
      overall survival (HR = 1.54, 95% CI 0.82, 2.91; P = 0.18) were noted when LUSI 
      was present. In patients with stage I endometrial cancer, the presence of LUSI is 
      associated with grade 3 tumor, deep myometrial invasion, and the presence of 
      CSLI. A larger group of patients is necessary to conclude whether higher 
      recurrence rate and poorer overall survival are associated with the presence of 
      LUSI.
FAU - Lavie, O
AU  - Lavie O
AD  - Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel. 
      olavie@zahav.net.il
FAU - Uriev, L
AU  - Uriev L
FAU - Gdalevich, M
AU  - Gdalevich M
FAU - Barak, F
AU  - Barak F
FAU - Peer, G
AU  - Peer G
FAU - Auslender, R
AU  - Auslender R
FAU - Anteby, E
AU  - Anteby E
FAU - Gemer, O
AU  - Gemer O
LA  - eng
PT  - Journal Article
DEP - 20071213
PL  - England
TA  - Int J Gynecol Cancer
JT  - International journal of gynecological cancer : official journal of the 
      International Gynecological Cancer Society
JID - 9111626
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Disease-Free Survival
MH  - Endometrial Neoplasms/epidemiology/*pathology/surgery/*therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Sentinel Lymph Node Biopsy
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2007/12/18 09:00
MHDA- 2009/01/08 09:00
CRDT- 2007/12/18 09:00
PHST- 2007/12/18 09:00 [pubmed]
PHST- 2009/01/08 09:00 [medline]
PHST- 2007/12/18 09:00 [entrez]
AID - IJG1150 [pii]
AID - 10.1111/j.1525-1438.2007.01150.x [doi]
PST - ppublish
SO  - Int J Gynecol Cancer. 2008 Sep-Oct;18(5):1079-83. doi: 
      10.1111/j.1525-1438.2007.01150.x. Epub 2007 Dec 13.