PMID- 18082573
OWN - NLM
STAT- MEDLINE
DCOM- 20080227
LR  - 20071217
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 11
DP  - 2007 Nov
TI  - HLA class I polymorphism in the Cuban population.
PG  - 918-27
AB  - The extreme polymorphism found at some of the human leukocyte antigen (HLA) 
      system loci makes it an invaluable tool for population genetic analyses. In the 
      present study the genetic polymorphism of the Cuban population was estimated at 
      HLA-A, -B, and -Cw loci by DNA typing. HLA class I allele and haplotype diversity 
      were determined in 390 unrelated Cuban individuals (188 whites and 202 mulattos) 
      from all over the country. In whites 19, 27, and 14 allele families for the 
      HLA-A, -B, and -Cw loci, respectively, were identified. In mulattos, for the same 
      loci, 20, 18, and 14 allele families were identified. Allele and haplotypes 
      frequencies, comparisons with other worldwide populations based on genetic 
      distances, neighbor-joining dendrograms, and correspondence analyses were 
      estimated. Most of the identified allele groups and haplotypes are also common to 
      sub-Saharan African and Europeans populations. However, Amerindian and Asian 
      alleles were also detected at lower frequencies. The results clearly reveal the 
      high diversity and interethnic admixture of the studied population. Our results 
      provide useful information for the further studies of the Cuban population 
      evolution and disease association in terms of HLA class I genes.
FAU - Ferrer, Annia
AU  - Ferrer A
AD  - Center of Genetic Engineering and Biotechnology, Havana, Cuba. 
      annia.ferrer@cigb.edu.cu
FAU - Nazabal, Marcelo
AU  - Nazabal M
FAU - Companioni, Osmel
AU  - Companioni O
FAU - Fernandez de Cossio, Maria E
AU  - Fernandez de Cossio ME
FAU - Camacho, Hanlet
AU  - Camacho H
FAU - Cintado, Alberto
AU  - Cintado A
FAU - Benitez, Jesus
AU  - Benitez J
FAU - Casalvilla, Racmar
AU  - Casalvilla R
FAU - Sautie, Miguel
AU  - Sautie M
FAU - Villareal, Adelaida
AU  - Villareal A
FAU - Diaz, Tamara
AU  - Diaz T
FAU - Marrero, Anisley
AU  - Marrero A
FAU - Fernandez de Cossio, Jorge
AU  - Fernandez de Cossio J
FAU - Hodelin, Abel
AU  - Hodelin A
FAU - Leal, Lester
AU  - Leal L
FAU - Ballester, Laura
AU  - Ballester L
FAU - Novoa, Lidia I
AU  - Novoa LI
FAU - Middleton, Derek
AU  - Middleton D
FAU - Duenas, Marta
AU  - Duenas M
LA  - eng
PT  - Journal Article
DEP - 20071011
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Cuba
MH  - Gene Frequency
MH  - Haplotypes
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Humans
MH  - Phylogeny
MH  - *Polymorphism, Genetic
EDAT- 2007/12/18 09:00
MHDA- 2008/02/28 09:00
CRDT- 2007/12/18 09:00
PHST- 2007/04/20 00:00 [received]
PHST- 2007/08/28 00:00 [revised]
PHST- 2007/09/05 00:00 [accepted]
PHST- 2007/12/18 09:00 [pubmed]
PHST- 2008/02/28 09:00 [medline]
PHST- 2007/12/18 09:00 [entrez]
AID - S0198-8859(07)00436-3 [pii]
AID - 10.1016/j.humimm.2007.09.002 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Nov;68(11):918-27. doi: 10.1016/j.humimm.2007.09.002. Epub 2007 
      Oct 11.