PMID- 18082974
OWN - NLM
STAT- MEDLINE
DCOM- 20080415
LR  - 20220330
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 151
IP  - 2
DP  - 2008 Jan 24
TI  - A comparison of the physiological, behavioral, neurochemical and microglial 
      effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse.
PG  - 533-43
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) and methamphetamine (METH) are 
      amphetamine analogues with similar persistent neurochemical effects in the mouse 
      which some have described as neurotoxicity. We attempted to identify dose 
      regimens of MDMA and METH with similar effects on behavioral and physiological 
      variables in the mouse, then quantified the effects of these dose regimens on 
      neurochemistry and microglial markers. Four discrete injections of saline, MDMA 
      (10, 20, or 30 mg/kg), or METH (5 or 10 mg/kg) were administered to mice at 2 h 
      intervals. Body weight was quantified immediately before each injection, and 2 h 
      after the last injection, while core temperature and locomotor activity were 
      continuously monitored via radiotelemetry. Mice were killed 72 h after the final 
      injection and brains were rapidly dissected on ice. Dopamine content in various 
      brain regions was quantified via high pressure liquid chromatography (HPLC), and 
      microglial activation was assessed by saturation binding of the peripheral 
      benzodiazepine receptor (PBR) ligand 
      1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide 
      ([(3)H]PK11195). Specific dose regimens of MDMA and METH induced similar 
      reductions in body weight, depletions of dopamine and its metabolites, and 
      similar hyperthermic and locomotor stimulant effects, but only METH activated 
      microglia in striatum. These results suggest that repeated high doses of MDMA and 
      METH that produce hyperthermia, locomotor stereotypy, weight loss and 
      neurochemical depletion are not consistently accompanied by microglial 
      activation. The finding that METH, but not MDMA, induces microglial effects in 
      the striatum consistent with neurotoxicity might imply different mechanisms of 
      toxic action for these two psychostimulants.
FAU - Fantegrossi, W E
AU  - Fantegrossi WE
AD  - Division of Neuroscience, Yerkes National Primate Research Center, Emory 
      University, 954 Gatewood Drive, Atlanta, GA 30322, USA. WEFantegrossi@uams.edu
FAU - Ciullo, J R
AU  - Ciullo JR
FAU - Wakabayashi, K T
AU  - Wakabayashi KT
FAU - De La Garza, R 2nd
AU  - De La Garza R 2nd
FAU - Traynor, J R
AU  - Traynor JR
FAU - Woods, J H
AU  - Woods JH
LA  - eng
GR  - P51 RR000165-460317/RR/NCRR NIH HHS/United States
GR  - F31 DA005923-03/DA/NIDA NIH HHS/United States
GR  - R01 DA004087/DA/NIDA NIH HHS/United States
GR  - DA04087/DA/NIDA NIH HHS/United States
GR  - DA05923/DA/NIDA NIH HHS/United States
GR  - R21 DA020645/DA/NIDA NIH HHS/United States
GR  - R21 DA020645-01/DA/NIDA NIH HHS/United States
GR  - F31 DA005923/DA/NIDA NIH HHS/United States
GR  - DA09161/DA/NIDA NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - R01 DA009161/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20071117
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Hallucinogens)
RN  - 0 (Isoquinolines)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - YNF83VN1RL (PK 11195)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Body Temperature/drug effects
MH  - Body Weight/drug effects
MH  - Brain/pathology
MH  - Brain Chemistry/*drug effects
MH  - Central Nervous System Stimulants/*toxicity
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Data Interpretation, Statistical
MH  - Dopamine/metabolism
MH  - Hallucinogens/*toxicity
MH  - Isoquinolines/metabolism
MH  - Male
MH  - Methamphetamine/*toxicity
MH  - Mice
MH  - Microglia/*drug effects
MH  - Motor Activity/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Neostriatum/drug effects/metabolism
PMC - PMC2276981
MID - NIHMS39191
EDAT- 2007/12/18 09:00
MHDA- 2008/04/16 09:00
PMCR- 2009/01/24
CRDT- 2007/12/18 09:00
PHST- 2007/09/07 00:00 [received]
PHST- 2007/11/06 00:00 [revised]
PHST- 2007/11/12 00:00 [accepted]
PHST- 2007/12/18 09:00 [pubmed]
PHST- 2008/04/16 09:00 [medline]
PHST- 2007/12/18 09:00 [entrez]
PHST- 2009/01/24 00:00 [pmc-release]
AID - S0306-4522(07)01406-6 [pii]
AID - 10.1016/j.neuroscience.2007.11.007 [doi]
PST - ppublish
SO  - Neuroscience. 2008 Jan 24;151(2):533-43. doi: 10.1016/j.neuroscience.2007.11.007. 
      Epub 2007 Nov 17.