PMID- 18086824
OWN - NLM
STAT- MEDLINE
DCOM- 20080110
LR  - 20220309
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 14
IP  - 12
DP  - 2007 Dec
TI  - Differential regional expression of brain-derived neurotrophic factor following 
      olfactory fear learning.
PG  - 816-20
AB  - We examined brain-derived neurotrophic factor (BDNF) mRNA expression across the 
      olfactory system following fear conditioning. Mice received 10 pairings of odor 
      with footshock or equivalent unpaired odors and shocks. We found increased BDNF 
      mRNA in animals receiving paired footshocks in the multiple regions examined 
      including the posterior piriform cortex (PPC) and basolateral amygdala (BLA). 
      This was in contrast to the unpaired and odor-alone treatments, where BDNF mRNA 
      was increased in the olfactory bulb (OB) and anterior piriform cortex (APC) only, 
      but not the higher olfactory areas. We propose that odor exposure increases 
      expression of BDNF in the OB and APC while the PPC and BLA increase BDNF mRNA 
      only when associative learning occurs.
FAU - Jones, Seth V
AU  - Jones SV
AD  - Department of Psychiatry and Behavioral Sciences, Yerkes Research Center, Emory 
      University, Atlanta, Georgia 30329, USA.
FAU - Stanek-Rattiner, Lisa
AU  - Stanek-Rattiner L
FAU - Davis, Michael
AU  - Davis M
FAU - Ressler, Kerry J
AU  - Ressler KJ
LA  - eng
GR  - R37 MH047840/MH/NIMH NIH HHS/United States
GR  - P51 RR000165/RR/NCRR NIH HHS/United States
GR  - R01 DA019624-01A2/DA/NIDA NIH HHS/United States
GR  - K01 MH069884/MH/NIMH NIH HHS/United States
GR  - DA-019624/DA/NIDA NIH HHS/United States
GR  - P51RR000165/RR/NCRR NIH HHS/United States
GR  - R01 DA019624/DA/NIDA NIH HHS/United States
GR  - MH069884/MH/NIMH NIH HHS/United States
GR  - R37 MH47840/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20071217
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amygdala/physiology
MH  - Animals
MH  - Association Learning/*physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Fear/*physiology
MH  - Gene Expression Regulation/*physiology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Odorants
MH  - Olfactory Bulb/physiology
MH  - Olfactory Pathways/*physiology
MH  - RNA, Messenger/metabolism
PMC - PMC2444033
MID - NIHMS55930
EDAT- 2007/12/19 09:00
MHDA- 2008/01/11 09:00
PMCR- 2008/12/01
CRDT- 2007/12/19 09:00
PHST- 2007/12/19 09:00 [pubmed]
PHST- 2008/01/11 09:00 [medline]
PHST- 2007/12/19 09:00 [entrez]
PHST- 2008/12/01 00:00 [pmc-release]
AID - 14/12/816 [pii]
AID - 10.1101/lm.781507 [doi]
PST - epublish
SO  - Learn Mem. 2007 Dec 17;14(12):816-20. doi: 10.1101/lm.781507. Print 2007 Dec.