PMID- 18087561
OWN - NLM
STAT- MEDLINE
DCOM- 20140502
LR  - 20171116
IS  - 1671-167X (Print)
IS  - 1671-167X (Linking)
VI  - 39
IP  - 6
DP  - 2007 Dec 18
TI  - [Long-term intensive glycemic and lipid control ameliorates the carotid intima 
      medial thickness in type 2 diabetes mellitus].
PG  - 649-52
AB  - OBJECTIVE: To investigate whether long-term intensive glycemic and lipid control 
      would ameliorate the carotid intima medial thickness (IMT) in patients with type 
      2 diabetes mellitus (T2DM). METHODS: IMT was evaluated on B-mode ultrasonography 
      in 116 patients with T2DM. Body mass index (BMI), waist-to-hip ratio (WHR), 
      fasting blood glucose (FBG), 2 hour postprandial glucose (2hPG), hemoglobin 
      A(1)c(HbA(1)c), total cholesterol(TC), triglycerides (TG), low-density 
      lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) were 
      also measured. Of all the patients 89 were divided randomly into group of 
      intensive glycemic and lipid control and group of conventional treatment and 
      underwent 1 year clinical interview. RESULTS: (1) IMT in patients with T2DM was 
      significantly correlated with age(r = 0.515,P = 0.000) , SBP (r = 0.208, P = 
      0.025), TC(r = 0.213,P = 0.022), LDL-C(r = 0.253, P = 0.006) and no correlations 
      were found between IMT and BMI,WHR,FBG, 2hPG ,HbA(1)c, TG and HDL-C. In 
      multivariate regression analysis, age (Beta = 0.527, P = 0.000 )and TC(Beta = 
      0.243, P = 0.002) were significant independent determinants for IMT. (3) After 1 
      year the change of IMT in the group of intensive glycemic and lipid control was 
      significantly different compared with the group of conventional treatment 
      [(-0.044+/-0.148)mm vs (0.056+/-0.178), P<0.05]. The change of IMT was not 
      significantly associated with the use of Metformin, Sulphonylurea and Aspirin, 
      but significantly associated with the use of statins. The change of IMT in the 
      group using statins was significantly different compared with that in the group 
      without using statins[(-0.053+/-0.153)mm vs (0.042+/-0.165)mm, P <0.05]. 
      CONCLUSION: Carotid IMT appears to be closely related to age and TC in the 
      patients with T2DM. long-term intensive glycemic control and lipid control could 
      ameliorate the IMT in patients with T2DM. The improvement of IMT may be 
      associated with the use of statin drug.
FAU - Yang, Jian Mei
AU  - Yang JM
AD  - Department of Endocrinology, Peking University First Hospital, Beijing 100034, 
      China.
FAU - Guo, Xiao Hui
AU  - Guo XH
FAU - Yu, Xiang
AU  - Yu X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Beijing Da Xue Xue Bao Yi Xue Ban
JT  - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health 
      sciences
JID - 101125284
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Hypolipidemic Agents)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/metabolism
MH  - Carotid Arteries/pathology
MH  - *Carotid Intima-Media Thickness
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/*pathology
MH  - Humans
MH  - Hypoglycemic Agents/administration & dosage/*therapeutic use
MH  - Hypolipidemic Agents/administration & dosage/*therapeutic use
MH  - Lipids/blood
MH  - Middle Aged
EDAT- 2007/12/19 09:00
MHDA- 2014/05/03 06:00
CRDT- 2007/12/19 09:00
PHST- 2007/12/19 09:00 [pubmed]
PHST- 2014/05/03 06:00 [medline]
PHST- 2007/12/19 09:00 [entrez]
PST - ppublish
SO  - Beijing Da Xue Xue Bao Yi Xue Ban. 2007 Dec 18;39(6):649-52.