PMID- 18089331
OWN - NLM
STAT- MEDLINE
DCOM- 20080220
LR  - 20171116
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 39
IP  - 10
DP  - 2007 Dec
TI  - Characterization of dendritic cell subsets in patients undergoing renal 
      transplantation.
PG  - 3101-4
AB  - Dendritic cells (DCs) play a key role in transplantation tolerance and immune 
      reactions to transplants. In order to ascertain whether DC levels are predictive 
      for rejection, we examined the levels and expression patterns of DCs of renal 
      transplant patients following immunosuppressive and/or surgical interventions. 
      Myeloid (HLA-DR+/CD11c+) and plasmacytoid (HLA-DR+/CD123+) DCs were characterized 
      by flow cytometry over 28 days. We demonstrated that myeloid DCs and plasmacytoid 
      DCs in peripheral blood were discernable and dramatically decreased following 
      renal transplantation and immunosuppression. Furthermore, the expression of CD62L 
      was significantly up-regulated (P=.032), while CD86 was significantly 
      down-regulated (P=.008) on myeloid but not plasmacytoid DCs. Although DC levels 
      alone were not predictive for the occurrence of a rejection episode, in 
      combination with other factors they may be indicative of rejection, thereby 
      sparing the patient a biopsy.
FAU - Fangmann, J
AU  - Fangmann J
AD  - Department of Surgery II, Clinic for Transplant Surgery, Leipzig, Germany.
FAU - Wegmann, C
AU  - Wegmann C
FAU - Hoppe, A
AU  - Hoppe A
FAU - Martin, P
AU  - Martin P
FAU - Sack, U
AU  - Sack U
FAU - Harms, J
AU  - Harms J
FAU - Faber, S
AU  - Faber S
FAU - Emmrich, F
AU  - Emmrich F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Antigens, CD)
RN  - 0 (CD11c Antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (IL3RA protein, human)
RN  - 0 (Interleukin-3 Receptor alpha Subunit)
RN  - 0 (Receptors, Interleukin-3)
SB  - IM
MH  - Antigens, CD/analysis
MH  - CD11c Antigen/analysis
MH  - Dendritic Cells/*classification/immunology
MH  - Graft Rejection/immunology
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - Interleukin-3 Receptor alpha Subunit/analysis
MH  - Kidney Transplantation/*immunology
MH  - Predictive Value of Tests
MH  - Receptors, Interleukin-3/analysis
MH  - Reference Values
EDAT- 2007/12/20 09:00
MHDA- 2008/02/21 09:00
CRDT- 2007/12/20 09:00
PHST- 2007/04/23 00:00 [received]
PHST- 2007/05/23 00:00 [accepted]
PHST- 2007/12/20 09:00 [pubmed]
PHST- 2008/02/21 09:00 [medline]
PHST- 2007/12/20 09:00 [entrez]
AID - S0041-1345(07)01245-6 [pii]
AID - 10.1016/j.transproceed.2007.05.088 [doi]
PST - ppublish
SO  - Transplant Proc. 2007 Dec;39(10):3101-4. doi: 10.1016/j.transproceed.2007.05.088.