PMID- 18091522
OWN - NLM
STAT- MEDLINE
DCOM- 20080129
LR  - 20131121
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 84
IP  - 11
DP  - 2007 Dec 15
TI  - Prevention of osteoporosis and hypogonadism by allogeneic ovarian transplantation 
      in conjunction with intra-bone marrow-bone marrow transplantation.
PG  - 1459-66
AB  - BACKGROUND: We investigated the effects of ovarian allograft in conjunction with 
      intra-bone marrow-bone marrow transplantation (IBM-BMT) on estrogen deficiency in 
      mice. METHODS: Female C57BL/6 mice underwent ovariectomy (OvX). After 3 months, 
      the mice were irradiated at 9.5 Gy, and the bone marrow cells (BMCs) of female 
      BALB/c mice (8 weeks old) were then injected into the bone cavity of the B6 mice. 
      Simultaneously, allogeneic ovaries from BALB/c mice were transplanted under the 
      renal capsules of the B6 mice. RESULTS: Three months after the transplantation, 
      the hematolymphoid cells were found to be completely reconstituted with 
      donor-derived cells. The transplanted ovary tissues under the renal capsules were 
      accepted without using immunosuppressants; there were a large number of growing 
      follicles at different stages of development. Atrophic endometrium and its glands 
      were also recovered by ovarian transplantation (OT). The transplanted allogeneic 
      ovaries secreted estrogen at normal levels. Furthermore, bone loss was prevented 
      to a certain extent. CONCLUSIONS: These findings suggest that IBM-BMT+OT will 
      become a valuable strategy for young women with malignant tumors to prevent 
      premature senescence, including hypogonadism and osteoporosis, after 
      radiochemotherapy.
FAU - Feng, Wei
AU  - Feng W
AD  - First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, 
      Japan.
FAU - Cui, Yunze
AU  - Cui Y
FAU - Song, Changye
AU  - Song C
FAU - Zhan, Hongsheng
AU  - Zhan H
FAU - Wang, Xiaoli
AU  - Wang X
FAU - Li, Qing
AU  - Li Q
FAU - Cui, Wenhao
AU  - Cui W
FAU - Guo, Kequan
AU  - Guo K
FAU - Maki, Masahiko
AU  - Maki M
FAU - Hisha, Hiroko
AU  - Hisha H
FAU - Mori, Takahide
AU  - Mori T
FAU - Ikehara, Susumu
AU  - Ikehara S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (Amino Acids)
RN  - 0 (Antigens)
RN  - 4TI98Z838E (Estradiol)
RN  - 90032-33-0 (deoxypyridinoline)
SB  - IM
MH  - Amino Acids/urine
MH  - Animals
MH  - Antigens/immunology
MH  - *Bone Marrow Transplantation/immunology
MH  - Estradiol/blood
MH  - Female
MH  - Hypogonadism/blood/immunology/*prevention & control/urine
MH  - Mice
MH  - Organ Size
MH  - Osteoporosis/blood/immunology/*prevention & control/urine
MH  - Ovary/immunology/*transplantation
MH  - Transplantation, Homologous/immunology
EDAT- 2007/12/20 09:00
MHDA- 2008/01/30 09:00
CRDT- 2007/12/20 09:00
PHST- 2007/12/20 09:00 [pubmed]
PHST- 2008/01/30 09:00 [medline]
PHST- 2007/12/20 09:00 [entrez]
AID - 00007890-200712150-00012 [pii]
AID - 10.1097/01.tp.0000288182.75398.74 [doi]
PST - ppublish
SO  - Transplantation. 2007 Dec 15;84(11):1459-66. doi: 
      10.1097/01.tp.0000288182.75398.74.