PMID- 18091530
OWN - NLM
STAT- MEDLINE
DCOM- 20080129
LR  - 20220311
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 84
IP  - 11
DP  - 2007 Dec 15
TI  - KIR/HLA ligand incompatibility in kidney transplantation.
PG  - 1527-33
AB  - BACKGROUND: The polymorphic family of killer-cell immunoglobulin-like receptors 
      (KIRs) consists of activating and inhibitory receptors expressed by natural 
      killer (NK) cells and effector T cells that recognize human leukocyte antigen 
      (HLA) class I ligands. It has been suggested that KIR/HLA incompatibility exerts 
      beneficial effects in hematopoietic stem cell transplantation. METHODS: To 
      elucidate whether certain receptor-ligand combinations between recipient KIR and 
      donor HLA antigens lead to enhanced alloreactivity of NK cells associated with 
      acute rejection (aRx) after kidney transplantation, we analyzed the entirety of 
      matches/mismatches between KIR genes and known HLA ligands for aRx patients 
      (n=105) compared to patients with stable renal function (n=119). RESULTS: Whereas 
      HLA-C ligand incompatibility between donor and recipient has no influence on aRx, 
      grafts derived from donors homozygous for HLA-C group 2 alleles seem to 
      demonstrate a better outcome (P=0.052). Additionally, a higher number of 
      inhibitory receptors in the recipient's genotype (P=0.042), a significant higher 
      number of matches for the receptors KIR2DL2/DS2 (P=0.004), as well as a higher 
      number of mismatches for KIR2DL3 (P=0.014) could be observed for patients with 
      stable renal function. CONCLUSION: Our data illustrate that certain KIR/HLA class 
      I ligand combinations between donor and recipient might influence graft 
      short-term outcome after renal transplantation.
FAU - Kunert, Kristina
AU  - Kunert K
AD  - Institute of Medical Immunology, Charite Universitatsmedizin Berlin, Campus 
      Mitte, Berlin, Germany.
FAU - Seiler, Marleen
AU  - Seiler M
FAU - Mashreghi, Mir Farzin
AU  - Mashreghi MF
FAU - Klippert, Katrin
AU  - Klippert K
FAU - Schonemann, Constanze
AU  - Schonemann C
FAU - Neumann, Konrad
AU  - Neumann K
FAU - Pratschke, Johann
AU  - Pratschke J
FAU - Reinke, Petra
AU  - Reinke P
FAU - Volk, Hans-Dieter
AU  - Volk HD
FAU - Kotsch, Katja
AU  - Kotsch K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
RN  - 0 (HLA Antigens)
RN  - 0 (Ligands)
RN  - EC 3.6.5.2 (GEM protein, human)
RN  - EC 3.6.5.2 (Monomeric GTP-Binding Proteins)
SB  - IM
MH  - Acute Disease
MH  - Female
MH  - Genotype
MH  - Graft Rejection/genetics/immunology
MH  - HLA Antigens/genetics/*immunology
MH  - Histocompatibility/*immunology
MH  - Humans
MH  - Kidney Transplantation/*immunology
MH  - Ligands
MH  - Male
MH  - Middle Aged
MH  - Monomeric GTP-Binding Proteins/genetics/*immunology
EDAT- 2007/12/20 09:00
MHDA- 2008/01/30 09:00
CRDT- 2007/12/20 09:00
PHST- 2007/12/20 09:00 [pubmed]
PHST- 2008/01/30 09:00 [medline]
PHST- 2007/12/20 09:00 [entrez]
AID - 00007890-200712150-00020 [pii]
AID - 10.1097/01.tp.0000290681.41859.41 [doi]
PST - ppublish
SO  - Transplantation. 2007 Dec 15;84(11):1527-33. doi: 
      10.1097/01.tp.0000290681.41859.41.