PMID- 18092230
OWN - NLM
STAT- MEDLINE
DCOM- 20080327
LR  - 20211203
IS  - 0897-7194 (Print)
IS  - 0897-7194 (Linking)
VI  - 25
IP  - 4
DP  - 2007 Aug
TI  - Coordinate regulation of ribosome biogenesis and function by the ribosomal 
      protein S6 kinase, a key mediator of mTOR function.
PG  - 209-26
AB  - Current understanding of the mechanisms by which cell growth is regulated lags 
      significantly behind our knowledge of the complex processes controlling cell 
      cycle progression. Recent studies suggest that the mammalian target of rapamycin 
      (mTOR) pathway is a key regulator of cell growth via the regulation of protein 
      synthesis. The key mTOR effectors of cell growth are eukaryotic initiation factor 
      4E-binding protein 1 (4EBP-1) and the ribosomal protein S6 kinase (S6K). Here we 
      will review the current models for mTOR dependent regulation of ribosome function 
      and biogenesis as well as its role in coordinating growth factor and nutrient 
      signaling to facilitate homeostasis of cell growth and proliferation. We will 
      place particular emphasis on the role of S6K1 signaling and will highlight the 
      points of cross talk with other key growth control pathways. Finally, we will 
      discuss the impact of S6K signaling and the consequent feedback regulation of the 
      PI3K/Akt pathway on disease processes including cancer.
FAU - Jastrzebski, Katarzyna
AU  - Jastrzebski K
AD  - Growth Control and Differentiation Program, Trescowthick Research Laboratories, 
      Peter MacCallum Cancer Centre, Melbourne, Australia.
FAU - Hannan, Katherine M
AU  - Hannan KM
FAU - Tchoubrieva, Elissaveta B
AU  - Tchoubrieva EB
FAU - Hannan, Ross D
AU  - Hannan RD
FAU - Pearson, Richard B
AU  - Pearson RB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Growth Factors
JT  - Growth factors (Chur, Switzerland)
JID - 9000468
RN  - 0 (RNA, Ribosomal)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Cell Growth Processes
MH  - Phosphatidylinositol 3-Kinases/metabolism
MH  - Protein Biosynthesis
MH  - Protein Kinases/metabolism
MH  - RNA, Ribosomal/biosynthesis
MH  - Ribosomal Protein S6 Kinases/chemistry/metabolism/*physiology
MH  - Ribosomes/*metabolism
MH  - Signal Transduction
MH  - TOR Serine-Threonine Kinases
RF  - 198
EDAT- 2007/12/20 09:00
MHDA- 2008/03/28 09:00
CRDT- 2007/12/20 09:00
PHST- 2007/12/20 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2007/12/20 09:00 [entrez]
AID - 787643975 [pii]
AID - 10.1080/08977190701779101 [doi]
PST - ppublish
SO  - Growth Factors. 2007 Aug;25(4):209-26. doi: 10.1080/08977190701779101.