PMID- 18092964
OWN - NLM
STAT- MEDLINE
DCOM- 20080401
LR  - 20071220
IS  - 0903-4641 (Print)
IS  - 0903-4641 (Linking)
VI  - 115
IP  - 11
DP  - 2007 Nov
TI  - A case of primary testicular germ cell tumor with rhabdomyosarcoma metastases as 
      an example of applying the FISH method to diagnostic pathology.
PG  - 1296-301
AB  - We present the interesting case of a 38-year-old man with a primary malignant 
      tumor of the right testis that metachronously metastasized to the urinary bladder 
      and the stomach. Histologically, the testicular tumor was a mixed germ cell tumor 
      composed of teratoma and embryonal carcinoma, but it also contained a sarcoma 
      component of somatic type malignancy. Metastases showed rhabdomyoblastic 
      differentiation histologically identical to the sarcoma component of the 
      testicular tumor that was diagnosed as rhabdomyosarcoma. By applying fluorescence 
      in situ hybridization (FISH) to the cytogenetic examination of cells taken from 
      the periventricular lymph node metastases, we demonstrated a structural 
      chromosomal aberration characteristic of testicular neoplasms, i.e. the presence 
      of isochromosome 12p (i(12p)). Additionally, the diagnosis was supported by 
      immunohistochemistry.
FAU - Korski, Konstanty
AU  - Korski K
AD  - Wielkopolska Cancer Center, Dept. of Pathology, Poznan, Poland. 
      konstanty.korski@wco.pl
FAU - Breborowicz, Danuta
AU  - Breborowicz D
FAU - Filas, Violetta
AU  - Filas V
FAU - Breborowicz, Jan
AU  - Breborowicz J
FAU - Grygalewicz, Beata
AU  - Grygalewicz B
FAU - Pienkowska-Grela, Barbara
AU  - Pienkowska-Grela B
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
SB  - IM
MH  - Adult
MH  - Diagnosis, Differential
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Male
MH  - Neoplasm Metastasis
MH  - Neoplasms, Germ Cell and Embryonal/*pathology/surgery
MH  - Rhabdomyosarcoma/*pathology/surgery
MH  - Stomach Neoplasms/secondary
MH  - Testicular Neoplasms/*pathology/surgery
MH  - Treatment Outcome
MH  - Urinary Bladder Neoplasms/secondary
EDAT- 2007/12/21 09:00
MHDA- 2008/04/02 09:00
CRDT- 2007/12/21 09:00
PHST- 2007/12/21 09:00 [pubmed]
PHST- 2008/04/02 09:00 [medline]
PHST- 2007/12/21 09:00 [entrez]
AID - APMapm_582.xml [pii]
AID - 10.1111/j.1600-0643.2007.00582.x [doi]
PST - ppublish
SO  - APMIS. 2007 Nov;115(11):1296-301. doi: 10.1111/j.1600-0643.2007.00582.x.