PMID- 18093285
OWN - NLM
STAT- MEDLINE
DCOM- 20080410
LR  - 20211020
IS  - 1471-2202 (Electronic)
IS  - 1471-2202 (Linking)
VI  - 8
DP  - 2007 Dec 19
TI  - Prenatal stress and subsequent exposure to chronic mild stress influence 
      dendritic spine density and morphology in the rat medial prefrontal cortex.
PG  - 107
AB  - BACKGROUND: Both prenatal stress (PS) and postnatal chronic mild stress (CMS) are 
      associated with behavioral and mood disturbances in humans and rodents. The aim 
      of this study was to reveal putative PS- and/or CMS-related changes in basal 
      spine morphology and density of pyramidal neurons in the rat medial prefrontal 
      cortex (mPFC). RESULTS: We show that rats exposed to PS and/or CMS display 
      changes in the morphology and number of basal spines on pyramidal neurons in the 
      mPFC. CMS had a negative effect on spine densities, particularly on spines of the 
      mushroom type, which are considered to form stronger and more stable synapses 
      than other spine types. PS alone did not affect spine densities, but had a 
      negative effect on the ratio of mushroom spines. In addition, PS seemed to make 
      rats less responsive to some of the negative effects of CMS, which supports the 
      notion that PS represents a predictive adaptive response. CONCLUSION: The 
      observed changes may represent a morphological basis of PS- and CMS-related 
      disturbances, and future studies in the field should not only consider total 
      spine densities, but also separate between different spine types.
FAU - Michelsen, Kimmo A
AU  - Michelsen KA
AD  - Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, 
      Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands. 
      k.michelsen@np.unimaas.nl
FAU - van den Hove, Daniel L A
AU  - van den Hove DL
FAU - Schmitz, Christoph
AU  - Schmitz C
FAU - Segers, Olivier
AU  - Segers O
FAU - Prickaerts, Jos
AU  - Prickaerts J
FAU - Steinbusch, Harry W M
AU  - Steinbusch HW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071219
PL  - England
TA  - BMC Neurosci
JT  - BMC neuroscience
JID - 100966986
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Cell Shape/physiology
MH  - Chronic Disease
MH  - Dendritic Spines/*pathology
MH  - Female
MH  - Image Cytometry
MH  - Male
MH  - Microscopy, Confocal
MH  - Microscopy, Electron, Transmission
MH  - Mood Disorders/etiology/*pathology/physiopathology
MH  - Prefrontal Cortex/abnormalities/*pathology/physiopathology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*pathology/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Stress, Physiological/complications/*pathology/physiopathology
MH  - Synapses/pathology
MH  - Synaptic Transmission/physiology
PMC - PMC2266759
EDAT- 2007/12/21 09:00
MHDA- 2008/04/11 09:00
PMCR- 2007/12/19
CRDT- 2007/12/21 09:00
PHST- 2007/03/14 00:00 [received]
PHST- 2007/12/19 00:00 [accepted]
PHST- 2007/12/21 09:00 [pubmed]
PHST- 2008/04/11 09:00 [medline]
PHST- 2007/12/21 09:00 [entrez]
PHST- 2007/12/19 00:00 [pmc-release]
AID - 1471-2202-8-107 [pii]
AID - 10.1186/1471-2202-8-107 [doi]
PST - epublish
SO  - BMC Neurosci. 2007 Dec 19;8:107. doi: 10.1186/1471-2202-8-107.