PMID- 18093624
OWN - NLM
STAT- MEDLINE
DCOM- 20081103
LR  - 20080623
IS  - 0034-5288 (Print)
IS  - 0034-5288 (Linking)
VI  - 85
IP  - 2
DP  - 2008 Oct
TI  - Comparison of Fick and thermodilution cardiac output determinations in standing 
      horses.
PG  - 307-14
AB  - The Fick and thermodilution (TD) methods are two currently popular techniques for 
      determination of cardiac output (CO) in adult horses. To our knowledge, a 
      comparison of these two techniques has not been reported. Six healthy, resting, 
      fit, adult horses of either sex and weighing 516.5+/-33.2 kg (mean+/-SD) were 
      instrumented to enable measurement of cardiac output. Resting CO was determined 
      by the Fick method and by thermodilution while the horses stood quietly in the 
      stocks. Fick and thermodilution CO measurements were repeated under conditions of 
      increased cardiac output achieved with the use of a dobutamine infusion (5 microg 
      kg(-1) min(-1), IV), and again under conditions of decreased CO induced by 
      administration of xylazine (0.5 mg/kg, IV). Fick and thermodilution cardiac 
      outputs were compared using Bland-Altman analysis for repeated measures. The mean 
      of the differences+/-1.96SD (bias and precision) between the two techniques was 
      1.88+/-24.17 L/min. Variability between measurements with the two techniques was 
      decreased to 3.41+/-46.78 mL kg(-1) min(-1) when CO was normalized for body size 
      by calculation of cardiac index.
FAU - Lepiz, Mauricio Loria
AU  - Lepiz ML
AD  - Department of Veterinary Clinical Sciences, College of Veterinary Medicine, 
      Washington State University, Pullman, WA 99164, United States. 
      mlepiz@cvm.tamu.edu
FAU - Keegan, Robert D
AU  - Keegan RD
FAU - Bayly, Warwick M
AU  - Bayly WM
FAU - Greene, Stephen A
AU  - Greene SA
FAU - McEwen, Margaret-Mary
AU  - McEwen MM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20080221
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
SB  - IM
MH  - Animals
MH  - Cardiac Output/*physiology
MH  - Female
MH  - Horses/*physiology
MH  - Indicator Dilution Techniques/veterinary
MH  - Male
EDAT- 2007/12/21 09:00
MHDA- 2008/11/04 09:00
CRDT- 2007/12/21 09:00
PHST- 2006/12/15 00:00 [received]
PHST- 2007/10/03 00:00 [revised]
PHST- 2007/10/25 00:00 [accepted]
PHST- 2007/12/21 09:00 [pubmed]
PHST- 2008/11/04 09:00 [medline]
PHST- 2007/12/21 09:00 [entrez]
AID - S0034-5288(07)00247-0 [pii]
AID - 10.1016/j.rvsc.2007.10.013 [doi]
PST - ppublish
SO  - Res Vet Sci. 2008 Oct;85(2):307-14. doi: 10.1016/j.rvsc.2007.10.013. Epub 2008 
      Feb 21.