PMID- 18095139
OWN - NLM
STAT- MEDLINE
DCOM- 20081014
LR  - 20071220
IS  - 1433-7398 (Print)
IS  - 1433-7398 (Linking)
VI  - 24
IP  - 1
DP  - 2007
TI  - Comparison of numerical change of epidermal growth factor receptor gene among 
      pre- and postradiation glioma, and gliosis, and its clinical use.
PG  - 15-8
AB  - Surgery with following chemoradiotherapy is the mainstream glioma treatment. In 
      the course of postradiation events, however, it is sometimes difficult for 
      neurosurgeons, radiologists, and pathologists to discriminate tumor recurrence 
      from radiation necrosis. The epidermal growth factor receptor (EGFR) gene, on 
      chromosome 7, is known to gain in copy number frequently in high-grade gliomas. 
      The authors applied the fluorescence in situ hybridization (FISH) method to 
      observe the gene's numerical status in pre- and postradiation glioma samples to 
      elucidate whether this technique is useful in the discrimination of glioma 
      recurrence from radiation necrosis. When 15 postradiation glioma samples and 4 
      postradiation nonglioma samples were tested, all the recurrent glioma tissue 
      harbored numerical aberrations of the gene, whereas no abnormality could be 
      observed in necrosis or in nonglioma gliosis. FISH could even prove a residual 
      glioma cell in a gliotic tissue taken by needle biopsy after gamma-knife 
      radiosurgery, which had been executed on a supposed metastatic brain tumor. FISH 
      is considered to be of help in accurate diagnosis, especially when the usual 
      histopathological diagnosis is difficult because of radiation effects or small 
      sample size.
FAU - Okada, Yoshifumi
AU  - Okada Y
AD  - Department of Neurosurgery, Dokkyo University School of Medicine, 880 
      Kitakobayashi, Mibu, Tochigi, 321-0293, Japan. yokada@dokkyomed.ac.jp
FAU - Ohno, Chihiro
AU  - Ohno C
FAU - Ueki, Keisuke
AU  - Ueki K
FAU - Ogino, Masahiro
AU  - Ogino M
FAU - Kawamoto, Shunsuke
AU  - Kawamoto S
FAU - Kim, Phyo
AU  - Kim P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20070525
PL  - Japan
TA  - Brain Tumor Pathol
JT  - Brain tumor pathology
JID - 9716507
SB  - IM
MH  - Adult
MH  - Aged
MH  - Brain Neoplasms/*genetics/pathology/radiotherapy
MH  - Female
MH  - *Genes, erbB-1
MH  - Glioma/*genetics/pathology/radiotherapy
MH  - Gliosis/etiology/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Radiation Injuries/*genetics/pathology
MH  - Radiotherapy/adverse effects
EDAT- 2007/12/21 09:00
MHDA- 2008/10/15 09:00
CRDT- 2007/12/21 09:00
PHST- 2007/01/09 00:00 [received]
PHST- 2007/02/15 00:00 [accepted]
PHST- 2007/12/21 09:00 [pubmed]
PHST- 2008/10/15 09:00 [medline]
PHST- 2007/12/21 09:00 [entrez]
AID - 10.1007/s10014-007-0213-5 [doi]
PST - ppublish
SO  - Brain Tumor Pathol. 2007;24(1):15-8. doi: 10.1007/s10014-007-0213-5. Epub 2007 
      May 25.