PMID- 18095485
OWN - NLM
STAT- MEDLINE
DCOM- 20080227
LR  - 20071221
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 59
IP  - 12
DP  - 2007 Dec
TI  - [Immune reconstitution inflammatory syndrome in the central nervous system].
PG  - 1355-62
AB  - The prognosis of HIV-related disorders have markedly improved after highly active 
      antiretroviral therapy was introduced, however, following initiation of the 
      therapy, some patients with severe immunodeficiency develop a paradoxical 
      clinical deterioration despite decreased HIV viral load and increased CD4+ T-cell 
      counts. These phenomena are recently recognized as immune reconstitution 
      inflammatory syndrome (IRIS). It is considered that the rapid restoration of the 
      immune system leads to exuberant inflammatory responses to antigenic stimuli. 
      Although the disorders are sometimes life-threatening, the definition and the 
      management of IRIS have not been established yet. We review the current knowledge 
      of IRIS, especially in the area of HIV-related CNS disorders. Cryptococcal 
      meningitis and progressive multifocal leukoencephalopathy (PML) are common 
      disorders which cause CNS IRIS. HIV encephalopathy is also reported to develope 
      IRIS. Infiltration of cytotoxic CD8+ T lymphocytes is observed in the suffered 
      brain tissue of PML and HIV encephalopathy, and it may be one of the pathogenic 
      factors.
FAU - Ohta, Keiko
AU  - Ohta K
AD  - Department of Neurology, Tokyo Metropolitan Komagome Hospital, 3-18-22 
      Honkomagome, Bunkyo-ku, Tokyo 113-8677, Japan.
FAU - Kishida, Shuji
AU  - Kishida S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
SB  - IM
MH  - Adult
MH  - *Central Nervous System Diseases/etiology
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome/etiology
MH  - Male
RF  - 34
EDAT- 2007/12/22 09:00
MHDA- 2008/02/28 09:00
CRDT- 2007/12/22 09:00
PHST- 2007/12/22 09:00 [pubmed]
PHST- 2008/02/28 09:00 [medline]
PHST- 2007/12/22 09:00 [entrez]
PST - ppublish
SO  - Brain Nerve. 2007 Dec;59(12):1355-62.