PMID- 18097601
OWN - NLM
STAT- MEDLINE
DCOM- 20080212
LR  - 20071221
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 19
IP  - 1
DP  - 2008 Jan
TI  - CD1c+ and CD303+ dendritic cells in peripheral blood, lymph nodes and tumor 
      tissue of patients with non-small cell lung cancer.
PG  - 237-43
AB  - Dendritic cells (DCs) are the most potent antigen presenting cells, which can 
      stimulate a cellular immune response against malignant tumor cells. Many authors 
      have described the phenomenon of tumor infiltration by dendritic cells and 
      emphasized an immunosuppressive tumor influence on DC function. In the present 
      study, we examined the presence of myeloid CD1c+ (BDCA-1+) dendritic cells and 
      lymphoid/plasmacytoid CD303+ (BDCA-2+) dendritic cells in peripheral blood, lymph 
      nodes and cancer tissue of patients with non-small cell lung cancer (NSCLC). 
      Fifty male patients treated surgically for NSCLC stages I-IIIa without 
      neoadjuvant chemotherapy were included. Employing a multiparameter flow cytometry 
      for CD1c, CD19, CD123 and CD303, we observed an accumulation of immature DCs in 
      the tissues involved in the neoplasmatic process with the predominance of 
      lymphoid/plasmacytoid over myeloid DCs. Moreover, in peripheral blood NSCLC 
      patients had a significantly lower percentage of CD1c+ DCs than healthy donors. 
      Our results suggest that NSCLC cells might hamper the maturation of DCs, thus 
      escaping an efficient immune response.
FAU - Tabarkiewicz, Jacek
AU  - Tabarkiewicz J
AD  - Department of Clinical Immunology, Skubiszewski Medical University, 20-095 
      Lublin, Poland. tabar@mp.pl
FAU - Rybojad, Pawel
AU  - Rybojad P
FAU - Jablonka, Andrzej
AU  - Jablonka A
FAU - Rolinski, Jacek
AU  - Rolinski J
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, CD1)
RN  - 0 (CD1C protein, human)
RN  - 0 (CLEC4C protein, human)
RN  - 0 (Glycoproteins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD/metabolism
MH  - Antigens, CD1/*metabolism
MH  - Carcinoma, Non-Small-Cell Lung/*immunology/metabolism/mortality
MH  - Cell Count
MH  - Dendritic Cells/*metabolism
MH  - Flow Cytometry
MH  - Glycoproteins/*metabolism
MH  - Humans
MH  - Immunophenotyping
MH  - Lectins, C-Type/*metabolism
MH  - Lung Neoplasms/*immunology/metabolism/mortality
MH  - Lymph Nodes/cytology/immunology
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Middle Aged
MH  - Receptors, Immunologic/*metabolism
EDAT- 2007/12/22 09:00
MHDA- 2008/02/13 09:00
CRDT- 2007/12/22 09:00
PHST- 2007/12/22 09:00 [pubmed]
PHST- 2008/02/13 09:00 [medline]
PHST- 2007/12/22 09:00 [entrez]
PST - ppublish
SO  - Oncol Rep. 2008 Jan;19(1):237-43.