PMID- 18097854
OWN - NLM
STAT- MEDLINE
DCOM- 20080124
LR  - 20191210
IS  - 1532-4303 (Electronic)
IS  - 0277-0903 (Linking)
VI  - 44
IP  - 10
DP  - 2007 Dec
TI  - Off-line fractional exhaled nitric oxide measurement is useful to screen allergic 
      airway inflammation in an adult population.
PG  - 805-10
AB  - To determine whether off-line fractional exhaled nitric oxide (FeNO) measurement 
      is applicable to screen allergic airway inflammation for epidemiologic studies, 
      we examined 280 adults, measuring off-line FeNO samplings, pulmonary function, 
      and serum immunoglobulin E (IgE). Subjects with recurrent wheeze (recurrent 
      wheezers) had significantly higher FeNO and IgE levels and significantly lower 
      forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) than 
      non-wheezers. Statistical analysis showed that FeNO and FEV1/FVC were significant 
      predictors for recurrent wheezers, independent of smoking. The cut-off FeNO level 
      for screening allergic airway inflammation was 38 ppb in non-smokers and 32.9 ppb 
      in smokers. Thus, off-line FeNO can be used as a good marker to screen allergic 
      airway inflammation, regardless of smoking.
FAU - Saito, Junpei
AU  - Saito J
AD  - Department of Pulmonary Medicine, School of Medicine, Fukushima Medical 
      University, Fukushima, Japan. junpei@fmu.ac.jp
FAU - Sato, Suguru
AU  - Sato S
FAU - Hasunuma, Hideki
AU  - Hasunuma H
FAU - Ishimaru, Yasushi
AU  - Ishimaru Y
FAU - Kanegae, Hiroshi
AU  - Kanegae H
FAU - Kudo, Shoji
AU  - Kudo S
FAU - Munakata, Mitsuru
AU  - Munakata M
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - England
TA  - J Asthma
JT  - The Journal of asthma : official journal of the Association for the Care of 
      Asthma
JID - 8106454
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Exhalation
MH  - Female
MH  - Humans
MH  - Inflammation/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nitric Oxide/*analysis
MH  - Respiratory Hypersensitivity/*metabolism
MH  - Respiratory Sounds
EDAT- 2007/12/22 09:00
MHDA- 2008/01/25 09:00
CRDT- 2007/12/22 09:00
PHST- 2007/12/22 09:00 [pubmed]
PHST- 2008/01/25 09:00 [medline]
PHST- 2007/12/22 09:00 [entrez]
AID - 788737903 [pii]
AID - 10.1080/02770900701645595 [doi]
PST - ppublish
SO  - J Asthma. 2007 Dec;44(10):805-10. doi: 10.1080/02770900701645595.