PMID- 1812219
OWN - NLM
STAT- MEDLINE
DCOM- 19920610
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 66
IP  - 6
DP  - 1991 Dec
TI  - Correlation of physiologically and morphologically identified neuronal types in 
      human association cortex in vitro.
PG  - 1825-37
AB  - 1. We examined whether the three physiologically defined neuron types described 
      for rodent neocortex were also evident in human association cortex studied in an 
      in vitro brain slice preparation. We also examined the relationship between 
      physiological and morphological cell type in human neocortical neurons. In 
      particular, we tested whether burst-firing neurons were numerous in regions of 
      human cortex that are susceptible to seizures. 2. Although we sampled 
      regular-spiking and fast-spiking neurons, we observed no true burst-firing 
      neurons, as defined for rodent cortex. We did find neurons that displayed a 
      voltage-dependent shift in firing behavior. Because this behavior was due, in 
      large part, to a low-threshold calcium conductance, we called these cells 
      low-threshold spike (LTS) neurons. 3. Regular-spiking neurons and LTS neurons 
      only differed in the voltage dependence of firing behavior and the first few 
      interspike intervals (ISIs) of repetitive firing in response to small current 
      injections (from hyperpolarized membrane potentials). Because of the general 
      similarities between the two types, we consider the LTS cells to be a subgroup of 
      regular-spiking cells. 4. All biocytin-filled regular-spiking neurons were spiny 
      and pyramidal and found in layers II-VI. The lone filled fast-spiking cell was 
      aspiny and nonpyramidal (layer V). The LTS neurons were morphologically 
      heterogeneous. We found 80% of LTS neurons to be spiny and pyramidal, but 20% 
      were aspiny nonpyramidal cells. LTS neurons were located in layers II-VI. 5. In 
      conclusion, human association cortex contains two of three physiological cell 
      types described in rodent cortex: regular spiking and fast spiking. These 
      physiological types corresponded to spiny, pyramidal, and aspiny, nonpyramidal 
      cells, respectively. We sampled no intrinsic burst-firing neurons in human 
      association cortex. LTS neurons exhibited voltage-dependent changes in firing 
      behavior and were morphologically heterogeneous: most LTS cells were spiny and 
      pyramidal, but two cells were found to be aspiny and nonpyramidal. It is not 
      clear whether the absence of burst-firing neurons or the morphological 
      heterogeneity of LTS neurons are due to species differences or differences in 
      cortical areas.
FAU - Foehring, R C
AU  - Foehring RC
AD  - Department of Anatomy and Neurobiology, University of Tennessee, Memphis 38163.
FAU - Lorenzon, N M
AU  - Lorenzon NM
FAU - Herron, P
AU  - Herron P
FAU - Wilson, C J
AU  - Wilson CJ
LA  - eng
GR  - NS-20743/NS/NINDS NIH HHS/United States
GR  - NS-27180/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Association Learning/*physiology
MH  - Axons/ultrastructure
MH  - Cerebral Cortex/*physiology/physiopathology
MH  - Electric Stimulation
MH  - Electrophysiology/methods
MH  - Epilepsy/physiopathology/surgery
MH  - Evoked Potentials
MH  - Humans
MH  - In Vitro Techniques
MH  - Membrane Potentials
MH  - Neurons/*physiology/ultrastructure
MH  - Pyramidal Tracts/cytology/physiology
MH  - Time Factors
EDAT- 1991/12/01 00:00
MHDA- 1991/12/01 00:01
CRDT- 1991/12/01 00:00
PHST- 1991/12/01 00:00 [pubmed]
PHST- 1991/12/01 00:01 [medline]
PHST- 1991/12/01 00:00 [entrez]
AID - 10.1152/jn.1991.66.6.1825 [doi]
PST - ppublish
SO  - J Neurophysiol. 1991 Dec;66(6):1825-37. doi: 10.1152/jn.1991.66.6.1825.