PMID- 18155927
OWN - NLM
STAT- MEDLINE
DCOM- 20080512
LR  - 20140325
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 39
IP  - 4
DP  - 2008 Feb 15
TI  - Is our self based on reward? Self-relatedness recruits neural activity in the 
      reward system.
PG  - 2066-75
AB  - Every organism has to evaluate incoming stimuli according to their current and 
      future significance. The immediate value of stimuli is coded by the reward 
      system, but the processing of their long-term relevance implements a valuation 
      system that implicates self-relatedness. The neuronal relationship between reward 
      and self-relatedness remains unclear though. Using event-related functional MRI, 
      we investigated whether self-relatedness induces neural activity in the reward 
      system. Self-relatedness induced signal changes in the same regions that were 
      recruited during reward including the bilateral nucleus accumbens (NACC), ventral 
      tegmental area (VTA) and ventromedial prefrontal cortex (VMPFC). The fMRI signal 
      time courses revealed no differences in early BOLD signals between reward and 
      self-relatedness. In contrast, both conditions differed in late BOLD signals with 
      self-relatedness showing higher signal intensity. In sum, our findings indicate 
      sustained recruitment of the reward system during self-relatedness. These 
      findings may contribute to a better understanding of the reward-based nature of 
      our self.
FAU - de Greck, M
AU  - de Greck M
AD  - Department of Psychiatry, Otto-von-Guericke University, Magdeburg, Germany.
FAU - Rotte, M
AU  - Rotte M
FAU - Paus, R
AU  - Paus R
FAU - Moritz, D
AU  - Moritz D
FAU - Thiemann, R
AU  - Thiemann R
FAU - Proesch, U
AU  - Proesch U
FAU - Bruer, U
AU  - Bruer U
FAU - Moerth, S
AU  - Moerth S
FAU - Tempelmann, C
AU  - Tempelmann C
FAU - Bogerts, B
AU  - Bogerts B
FAU - Northoff, G
AU  - Northoff G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071119
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Alcohol Drinking/psychology
MH  - *Ego
MH  - Female
MH  - Food
MH  - Functional Laterality/physiology
MH  - Gambling
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Nucleus Accumbens/physiology
MH  - Oxygen/blood
MH  - Prefrontal Cortex/physiology
MH  - Reaction Time/physiology
MH  - Recruitment, Neurophysiological/*physiology
MH  - *Reward
MH  - Self Concept
MH  - Ventral Tegmental Area/physiology
EDAT- 2007/12/25 09:00
MHDA- 2008/05/13 09:00
CRDT- 2007/12/25 09:00
PHST- 2007/07/16 00:00 [received]
PHST- 2007/10/10 00:00 [revised]
PHST- 2007/11/01 00:00 [accepted]
PHST- 2007/12/25 09:00 [pubmed]
PHST- 2008/05/13 09:00 [medline]
PHST- 2007/12/25 09:00 [entrez]
AID - S1053-8119(07)01032-4 [pii]
AID - 10.1016/j.neuroimage.2007.11.006 [doi]
PST - ppublish
SO  - Neuroimage. 2008 Feb 15;39(4):2066-75. doi: 10.1016/j.neuroimage.2007.11.006. 
      Epub 2007 Nov 19.