PMID- 18158708
OWN - NLM
STAT- MEDLINE
DCOM- 20080212
LR  - 20150330
IS  - 1479-1641 (Print)
IS  - 1479-1641 (Linking)
VI  - 4
IP  - 4
DP  - 2007 Dec
TI  - Beneficial effects of ramipril on myocardial diastolic function in patients with 
      type 2 diabetes mellitus, normal LV systolic function and without coronary artery 
      disease: a prospective study using tissue Doppler.
PG  - 358-64
AB  - Angiotensin-converting enzyme (ACE) inhibitors can improve cardiovascular outcome 
      in patients with type 2 diabetes mellitus (T2DM). Myocardial diastolic function 
      (Ve) is a known marker of cardiovascular prognosis. It could potentially indicate 
      the effects of preventive therapy if evaluated by tissue Doppler. We tested the 
      hypothesis that treatment with the ACE inhibitor ramipril has beneficial effects 
      on Ve. In this study, 16 subjects on insulin therapy (eight receiving 10 mg 
      ramipril/day compared to eight matched controls who were not treated with an ACE 
      inhibitor) were followed up for a period of nine months. Myocardial and vascular 
      function were assessed by tissue Doppler and ultrasound. In the ramipril group, 
      Ve improved significantly after nine months of treatment (7.8+/-0.9 cm/s to 
      8.6+/-0.9 cm/s, p<0.04). Systolic blood pressure and intima media thickness (IMT) 
      demonstrated a trend towards improvement. In controls, Ve remained unchanged and 
      there was a trend towards deterioration in stiffness index beta (p<0.07). In 
      conclusion, the observed improvement of myocardial diastolic function with 
      ramipril in patients with T2DM is an encouraging result. It might contribute to 
      the overall improvement that has been observed with hard cardiovascular end 
      points.
FAU - Siegmund, Thorsten
AU  - Siegmund T
AD  - Department of Endocrinology, Diabetes and Vascular Medicine, Academic Teaching 
      Hospital Munich-Bogenhausen, Munich, Germany. thorsten_siegmund@gmx.de
FAU - Schumm-Draeger, Petra-Maria
AU  - Schumm-Draeger PM
FAU - Antoni, Diethmar
AU  - Antoni D
FAU - Bibra, Helene Von
AU  - Bibra HV
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - L35JN3I7SJ (Ramipril)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiotensin-Converting Enzyme Inhibitors/*therapeutic use
MH  - Diabetes Mellitus, Type 2/*drug therapy/metabolism
MH  - Diastole/*drug effects
MH  - Echocardiography, Doppler
MH  - Female
MH  - Hemodynamics/drug effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Ramipril/*therapeutic use
MH  - Systole/drug effects
MH  - Ventricular Function/*drug effects/physiology
EDAT- 2007/12/26 09:00
MHDA- 2008/02/13 09:00
CRDT- 2007/12/26 09:00
PHST- 2007/12/26 09:00 [pubmed]
PHST- 2008/02/13 09:00 [medline]
PHST- 2007/12/26 09:00 [entrez]
AID - 2905 [pii]
AID - 10.3132/dvdr.2007.065 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2007 Dec;4(4):358-64. doi: 10.3132/dvdr.2007.065.