PMID- 18160197 OWN - NLM STAT- MEDLINE DCOM- 20080702 LR - 20220316 IS - 0278-5846 (Print) IS - 0278-5846 (Linking) VI - 32 IP - 3 DP - 2008 Apr 1 TI - Stress at work alters serum brain-derived neurotrophic factor (BDNF) levels and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in healthy volunteers: BDNF and MHPG as possible biological markers of mental stress? PG - 679-85 AB - There is growing evidence that blood levels of brain-derived neurotrophic factor (BDNF) and catecholamine, and cytokines are related to not only to depressive, suicidal, and anxious states but also to depression-associated personality traits. Psychological job stress is well known to lead to symptoms of depression and anxiety. In the present study, we examined effects of psychological job stress on serum levels of BDNF and plasma levels of catecholamine metabolites, and cytokines in healthy volunteers (n=106, male/female=42/64, age=36+/-12 yr) working in a hospital setting. The values (mean+/-SD) of scores for stress items in the Stress and Arousal Check List (s-SACL), plasma MHPG levels, and, serum BDNF levels in all participants were 7.2+/-3.3, 5.2+/-3.4 ng/mL, and 23.3+/-14.7 ng/mL, respectively. A negative correlation was found between scores for s-SACL and serum BDNF levels (rho=-0.211, p=0.022). A positive correlation was also found between scores on the s-SACL and plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) (rho=0.416, p=0.01), but not homovanillic acid (HVA). No relationship was found between s-SACL scores and plasma levels of interleukin-6 (IL-6) or tumor necrosis factor alpha (TNFalpha). These results suggest that serum BDNF levels and plasma MHPG levels might be biological markers reflective of psychological job stress in hospital employees. FAU - Mitoma, Masae AU - Mitoma M AD - Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka 8078555, Japan. FAU - Yoshimura, Reiji AU - Yoshimura R FAU - Sugita, Atsuko AU - Sugita A FAU - Umene, Wakako AU - Umene W FAU - Hori, Hikaru AU - Hori H FAU - Nakano, Hideki AU - Nakano H FAU - Ueda, Nobuhisa AU - Ueda N FAU - Nakamura, Jun AU - Nakamura J LA - eng PT - Comparative Study PT - Journal Article DEP - 20071117 PL - England TA - Prog Neuropsychopharmacol Biol Psychiatry JT - Progress in neuro-psychopharmacology & biological psychiatry JID - 8211617 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Catecholamines) RN - 0 (Cytokines) RN - 534-82-7 (Methoxyhydroxyphenylglycol) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Catecholamines/blood MH - Chromatography, High Pressure Liquid/methods MH - Cytokines/blood MH - Electrochemistry/methods MH - Female MH - Humans MH - Immunoassay/methods MH - Male MH - Methoxyhydroxyphenylglycol/*blood MH - Middle Aged MH - Statistics, Nonparametric MH - Stress, Psychological/*blood EDAT- 2007/12/28 09:00 MHDA- 2008/07/03 09:00 CRDT- 2007/12/28 09:00 PHST- 2007/08/27 00:00 [received] PHST- 2007/11/09 00:00 [revised] PHST- 2007/11/09 00:00 [accepted] PHST- 2007/12/28 09:00 [pubmed] PHST- 2008/07/03 09:00 [medline] PHST- 2007/12/28 09:00 [entrez] AID - S0278-5846(07)00403-4 [pii] AID - 10.1016/j.pnpbp.2007.11.011 [doi] PST - ppublish SO - Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):679-85. doi: 10.1016/j.pnpbp.2007.11.011. Epub 2007 Nov 17.