PMID- 18160825
OWN - NLM
STAT- MEDLINE
DCOM- 20080919
LR  - 20080709
IS  - 1422-6421 (Electronic)
IS  - 1422-6405 (Linking)
VI  - 188
IP  - 1-2
DP  - 2008
TI  - Tenascin C in stem cell niches: redundant, permissive or instructive?
PG  - 170-7
AB  - The stem cell niche provides the specialized environment that is able to sustain 
      the lifelong maintenance of stem cells in their discrete locations within organs. 
      The niche is usually composed of several different cell types and a specialized 
      extracellular matrix consisting of many different constituents. Additionally, a 
      variety of growth factors are secreted into the extracellular space and 
      contribute to the functional organization of the niche. Here, I will concentrate 
      on the multimodular extracellular matrix glycoprotein tenascin C (Tnc) and 
      discuss it as an exemplary molecule that is present in several stem cell niches. 
      In spite of its intuitively suggestive presence, it has been difficult to provide 
      functional evidence for the importance of Tnc in the context of stem cells. In 
      the nervous system, the careful analysis of Tnc-deficient mice has revealed that 
      the developmental program neural stem cell pass-through is delayed due to changes 
      in growth factor responsiveness. To gain further insight, we have employed the 
      gene trap technology in neural stem cells to identify potential Tnc target genes. 
      This approach has surfaced 2 interesting candidates that may contribute to a 
      better understanding of the signal(s) elicited by Tnc in neural stem/progenitor 
      cells in the niche.
CI  - (c) 2007 S. Karger AG, Basel.
FAU - von Holst, Alexander
AU  - von Holst A
AD  - Department of Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, 
      Bochum, Germany. Alexander.vonHolst@ruhr-uni-bochum.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071221
PL  - Switzerland
TA  - Cells Tissues Organs
JT  - Cells, tissues, organs
JID - 100883360
RN  - 0 (Tenascin)
SB  - IM
MH  - Animals
MH  - Neurons/cytology/metabolism
MH  - Signal Transduction
MH  - Stem Cells/*metabolism
MH  - Tenascin/chemistry/*metabolism
RF  - 79
EDAT- 2007/12/28 09:00
MHDA- 2008/09/20 09:00
CRDT- 2007/12/28 09:00
PHST- 2007/12/28 09:00 [pubmed]
PHST- 2008/09/20 09:00 [medline]
PHST- 2007/12/28 09:00 [entrez]
AID - 000112848 [pii]
AID - 10.1159/000112848 [doi]
PST - ppublish
SO  - Cells Tissues Organs. 2008;188(1-2):170-7. doi: 10.1159/000112848. Epub 2007 Dec 
      21.