PMID- 18161328
OWN - NLM
STAT- MEDLINE
DCOM- 20100617
LR  - 20161018
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 25
IP  - 5
DP  - 2007 Sep
TI  - [Chiral separation of tenatoprazole enantiomers using high performance liquid 
      chromatography on vacomycin-bonded chiral stationary phase].
PG  - 732-4
AB  - Vacomycin-bonded chiral stationary phase was used for the direct chiral 
      separation of tenatoprazole enantiomers using reversed-phase high performance 
      liquid chromatography (HPLC). The influences of the kinds and concentration of 
      buffer and organic modifier, the pH value of buffer, column length and column 
      temperature on the separation were examined. The chiral HPLC method for the 
      separation of tenatoprazole enantiomers on a Chirobiotic V column (150 mm x 4.6 
      mm, 5 microm) was established with simplicity and good reproducibility using 0.02 
      mol/L ammonium acetate buffer (pH 6.0)-tetrahydrofuran (93:7, v/v) as the mobile 
      phase at a flow rate of 0.5 mL/min and 20 degrees C. Under the above conditions, 
      the enantiomers were separated on baseline with the resolution of 1.68. The 
      relative standard deviations (RSDs) for the retention times of tenatoprazole 
      enantiomers were 0.48% and 0.49% (n = 6). The RSDs for the peak areas of 
      tenatoprazole enantiomers were 0.45% and 0.55% (n = 6).
FAU - Guan, Jin
AU  - Guan J
AD  - School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
FAU - Yang, Jing
AU  - Yang J
FAU - Bi, Yujin
AU  - Bi Y
FAU - Shi, Shuang
AU  - Shi S
FAU - Li, Famei
AU  - Li F
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Imidazoles)
RN  - KG60484QX9 (Omeprazole)
RN  - RE0689TX2K (Tenatoprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Chromatography, High Pressure Liquid/*instrumentation/*methods
MH  - Hydrogen-Ion Concentration
MH  - Imidazoles/*chemistry/*isolation & purification
MH  - Molecular Structure
MH  - Omeprazole/*analogs & derivatives/chemistry/isolation & purification
MH  - Reproducibility of Results
MH  - Stereoisomerism
EDAT- 2007/12/29 09:00
MHDA- 2010/06/18 06:00
CRDT- 2007/12/29 09:00
PHST- 2007/12/29 09:00 [pubmed]
PHST- 2010/06/18 06:00 [medline]
PHST- 2007/12/29 09:00 [entrez]
PST - ppublish
SO  - Se Pu. 2007 Sep;25(5):732-4.