PMID- 18162703
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20220408
IS  - 1011-8934 (Print)
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Linking)
VI  - 22
IP  - 6
DP  - 2007 Dec
TI  - Mechanisms of epithelial-mesenchymal transition of peritoneal mesothelial cells 
      during peritoneal dialysis.
PG  - 943-5
AB  - A growing body of evidence indicates that epithelial-mesenchymal transition (EMT) 
      of human peritoneal mesothelial cells (HPMC) may play an important role in the 
      development and progression of peritoneal fibrosis during long-term peritoneal 
      dialysis (PD) leading to failure of peritoneal membrane function. Here, we review 
      our own observations and those of others on the mechanisms of EMT of HPMC and 
      suggest potential therapeutic strategies to prevent EMT and peritoneal fibrosis 
      during long-term PD. We found that high glucose and H2O2 as well as transforming 
      growth factor-beta1 (TGF-beta1) induced EMT in HPMC and that high glucoseinduced 
      EMT was blocked not only by inhibition of TGF-beta1 but also by antioxidants or 
      inhibitors of mitogen-activated protein kinases (MAPK). Since MAPKs are 
      downstream target molecules of reactive oxygen species (ROS), these data suggest 
      that high glucose-induced generation of ROS and subsequent MAPK activation 
      mediate high glucose-induced EMT in HPMC. We and others also observed that bone 
      morphogenetic protein-7 (BMP-7) prevented EMT in HPMC. Glucose degradation 
      products (GDP) were shown to play a role in inducing EMT. Involvement of a 
      mammalian target of rapamycin (mTOR) in TGF-beta1-induced EMT has also been 
      proposed in cultured HPMC. A better understanding of the precise mechanisms 
      involved in EMT of HPMC may provide new therapeutic strategies for inhibiting 
      peritoneal fibrosis in long-term PD patients.
FAU - Lee, Hi Bahl
AU  - Lee HB
AD  - Hyonam Kidney Laboratory, Soon Chun Hyang University, Seoul, Korea.
FAU - Ha, Hunjoo
AU  - Ha H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
SB  - IM
MH  - Epithelial Cells/*pathology
MH  - Fibrosis
MH  - Humans
MH  - Mesoderm/*pathology
MH  - Peritoneal Dialysis/*adverse effects
MH  - Peritoneum/*pathology
PMC - PMC2694643
EDAT- 2007/12/29 09:00
MHDA- 2008/02/27 09:00
PMCR- 2007/12/01
CRDT- 2007/12/29 09:00
PHST- 2007/12/29 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2007/12/29 09:00 [entrez]
PHST- 2007/12/01 00:00 [pmc-release]
AID - 200712943 [pii]
AID - 10.3346/jkms.2007.22.6.943 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2007 Dec;22(6):943-5. doi: 10.3346/jkms.2007.22.6.943.