PMID- 18164790
OWN - NLM
STAT- MEDLINE
DCOM- 20080327
LR  - 20220318
IS  - 1532-1940 (Electronic)
IS  - 0266-4356 (Linking)
VI  - 46
IP  - 3
DP  - 2008 Apr
TI  - Matrix metalloproteinase and its inhibitor in temporomandibular joint 
      osteoarthrosis after indirect trauma in young goats.
PG  - 192-197
LID - S0266-4356(07)00482-2 [pii]
LID - 10.1016/j.bjoms.2007.10.007 [doi]
AB  - Our aim was to examine the change in expression of matrix metalloproteinases 
      (MMP-13), matrix metalloproteinases-3 (MMP-3), and tissue inhibitor of matrix 
      metalloproteinase-1 (TIMP-1) in the articular cartilage of goats with 
      experimentally-induced osteoarthrosis of the temporomandibular joint (TMJ) at 
      various times. Osteoarthrosis was induced in 20 goats in the bilateral TMJ and 5 
      goats acted as controls. There were 5 goats in each group, and a group was killed 
      at 7 days, and 1, 3, and 6 months postoperatively. The samples were collected, 
      and the joints evaluated histologically. Immunofluorescence was used to detect 
      the presence of MMPs and TIMP-1 in the articular disc and condylar cartilage. The 
      ultrastructure of the articular disc and condylar surface at 1 month was examined 
      with scanning electron microscopy (SEM). Osteoarthrosis of the TMJ progressed 
      gradually over time. MMP-13, MMP-3, and TIMP-1 were expressed strongly in the TMJ 
      soon after injury; MMP-13 became gradually weakened, and MMP-3 strengthened 
      later. None of these were expressed in the normal condyle. After a month the 
      surface of the arthrotic condyle was uneven, and the underlying collagen fibrils 
      were exposed in irregular fissures on the surface. The secretion of TIMP-1 was 
      related closely to the changes of MMPs during osteoarthrosis of the TMJ. The 
      unbalanced ratio between them caused degradation of the matrix of the cartilage 
      and might be the cause of osteoarthrosis of the TMJ.
FAU - Wang, Yan-Liang
AU  - Wang YL
AD  - Department of Oral Maxillofacial Surgery, Qin Du Stomatology Hospital, Fourth 
      Military Medical University, Xi'an 710032, PR China. Electronic address: 
      wangyanliang@hotmail.com.
FAU - Li, Xin-Jun
AU  - Li XJ
AD  - Department of Oral Maxillofacial Surgery, Qin Du Stomatology Hospital, Fourth 
      Military Medical University, Xi'an 710032, PR China.
FAU - Qin, Rui-Feng
AU  - Qin RF
AD  - Department of Oral Maxillofacial Surgery, Qin Du Stomatology Hospital, Fourth 
      Military Medical University, Xi'an 710032, PR China.
FAU - Lei, De-Lin
AU  - Lei DL
AD  - Department of Oral Maxillofacial Surgery, Qin Du Stomatology Hospital, Fourth 
      Military Medical University, Xi'an 710032, PR China.
FAU - Liu, Yan-Pu
AU  - Liu YP
AD  - Department of Oral Maxillofacial Surgery, Qin Du Stomatology Hospital, Fourth 
      Military Medical University, Xi'an 710032, PR China.
FAU - Wu, Gao-Yi
AU  - Wu GY
AD  - Department of Oral Maxillofacial Surgery, Qin Du Stomatology Hospital, Fourth 
      Military Medical University, Xi'an 710032, PR China.
FAU - Zhang, Yong-Jie
AU  - Zhang YJ
AD  - Center of Tissue Engineering, Fourth Military Medical University, Xi'an 710032, 
      PR China.
FAU - Yan-Jin
AU  - Yan-Jin
AD  - Center of Tissue Engineering, Fourth Military Medical University, Xi'an 710032, 
      PR China.
FAU - Wang, Da-Zhang
AU  - Wang DZ
AD  - Department of Oral Maxillofacial Surgery, Hua Xi Stomatology Hospital, Sichuan 
      University, Cheng Du 610041, PR China.
FAU - Hu, Kai-Jin
AU  - Hu KJ
AD  - Department of Oral Maxillofacial Surgery, Qin Du Stomatology Hospital, Fourth 
      Military Medical University, Xi'an 710032, PR China. Electronic address: 
      wangyanliang@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20071231
PL  - Scotland
TA  - Br J Oral Maxillofac Surg
JT  - The British journal of oral & maxillofacial surgery
JID - 8405235
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.- (Matrix Metalloproteinase 13)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - Cartilage, Articular/enzymology
MH  - Cattle
MH  - Goats
MH  - Male
MH  - Mandibular Condyle/ultrastructure
MH  - Matrix Metalloproteinase 13/*analysis
MH  - Matrix Metalloproteinase 3/*analysis
MH  - Osteoarthritis/*enzymology
MH  - Rabbits
MH  - Surface Properties
MH  - Temporomandibular Joint/injuries/ultrastructure
MH  - Temporomandibular Joint Disc/ultrastructure
MH  - Temporomandibular Joint Disorders/*enzymology/etiology
MH  - Time Factors
MH  - Tissue Inhibitor of Metalloproteinase-1/*analysis
EDAT- 2008/01/01 09:00
MHDA- 2008/03/28 09:00
CRDT- 2008/01/01 09:00
PHST- 2007/10/01 00:00 [accepted]
PHST- 2008/01/01 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2008/01/01 09:00 [entrez]
AID - S0266-4356(07)00482-2 [pii]
AID - 10.1016/j.bjoms.2007.10.007 [doi]
PST - ppublish
SO  - Br J Oral Maxillofac Surg. 2008 Apr;46(3):192-197. doi: 
      10.1016/j.bjoms.2007.10.007. Epub 2007 Dec 31.