PMID- 18164815
OWN - NLM
STAT- MEDLINE
DCOM- 20080424
LR  - 20131121
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 432
IP  - 1
DP  - 2008 Feb 13
TI  - Chronic microinjection of valproic acid into the nucleus accumbens attenuates 
      amphetamine-induced locomotor activity.
PG  - 54-7
LID - 10.1016/j.neulet.2007.12.005 [doi]
AB  - Amphetamine (AMPH)-induced hyper-locomotion has been well manifested in an animal 
      model of psychiatric diseases such as drug addiction and bipolar disorder. In 
      this study, we investigated the effects on AMPH-induced locomotor activity of 
      chronically microinjected valproic acid into the nucleus accumbens (NAcc). Rats 
      with guide cannular implanted bilaterally were divided into three groups and 
      either saline or valproic acid (100 or 300 microg/0.5 microl/side) was 
      microinjected into the NAcc once daily for 7 days. On day 8, half of each group 
      received either saline or AMPH (1mg/kg, i.p.), respectively, and locomotor 
      activity was measured for 2h. The increases of both horizontal locomotion and 
      rearing by AMPH were attenuated in the rat pre-treated with valproic acid 
      compared to saline in a dose-dependent manner. These results indicate that 
      neuronal modifications in the NAcc induced by chronic valproic acid can modulate 
      amphetamine-induced locomotor activity.
FAU - Kim, Wha Young
AU  - Kim WY
AD  - Department of Physiology, Brain Korea 21 Project for Medical Science, Brain 
      Research Institute, Yonsei University College of Medicine, 134 Shinchondong, 
      Seodaemungu, Seoul 120-752, South Korea.
FAU - Kim, Seungwoo
AU  - Kim S
FAU - Kim, Jeong-Hoon
AU  - Kim JH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071208
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Anticonvulsants)
RN  - 0 (Central Nervous System Stimulants)
RN  - 614OI1Z5WI (Valproic Acid)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Amphetamine/*toxicity
MH  - Animals
MH  - Anticonvulsants/*pharmacology
MH  - Central Nervous System Stimulants/*toxicity
MH  - Disease Models, Animal
MH  - Drug Interactions
MH  - Hyperkinesis/chemically induced/*drug therapy/physiopathology
MH  - Male
MH  - Microinjections
MH  - Motor Activity/drug effects
MH  - Nucleus Accumbens/*drug effects/physiopathology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Valproic Acid/*pharmacology
EDAT- 2008/01/01 09:00
MHDA- 2008/04/25 09:00
CRDT- 2008/01/01 09:00
PHST- 2007/08/27 00:00 [received]
PHST- 2007/12/01 00:00 [revised]
PHST- 2007/12/05 00:00 [accepted]
PHST- 2008/01/01 09:00 [pubmed]
PHST- 2008/04/25 09:00 [medline]
PHST- 2008/01/01 09:00 [entrez]
AID - S0304-3940(07)01261-X [pii]
AID - 10.1016/j.neulet.2007.12.005 [doi]
PST - ppublish
SO  - Neurosci Lett. 2008 Feb 13;432(1):54-7. doi: 10.1016/j.neulet.2007.12.005. Epub 
      2007 Dec 8.