PMID- 18164855
OWN - NLM
STAT- MEDLINE
DCOM- 20080609
LR  - 20191210
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 71
IP  - 1
DP  - 2008 May 1
TI  - Relevance of biologically equivalent dose values in outcome evaluation of 
      stereotactic radiotherapy for lung nodules.
PG  - 145-51
LID - 10.1016/j.ijrobp.2007.09.036 [doi]
AB  - PURPOSE: Different biologically equivalent dose (BED) values associated with 
      stereotactic radiotherapy (SRT) of patients with primary and metastatic pulmonary 
      nodules were studied. The BED values were calculated for tumoral tissue and low 
      alpha/beta ratio, assuming that better local response could be obtained by using 
      stereotactic high-BED treatment. METHODS AND MATERIALS: Fifty-eight patients with 
      T1-T3 N0 non-small-cell lung cancer and 46 patients with metastatic lung nodules 
      were treated with SRT. The BED was calculated for alpha/beta ratios of 3 and 10. 
      Overall survival (OS) was assessed according to Kaplan-Meier and appraised as a 
      function of three BED levels: low (30-50 Gy), medium (50-70 Gy), and high (70-98 
      Gy; alpha/beta = 10). RESULTS: The OS rates for all 104 patients at 12, 24, and 
      36 months were 73%, 48.3%, and 35.8%, respectively. Local response greater than 
      50% for low, medium, and high BED values was observed in 54%, 47%, and 73%, 
      respectively. In the high-BED treated group, OS rates at 12, 24, and 36 months 
      (80.9%, 70%, and 53.6%, respectively) were significantly improved compared with 
      low- (69%, 46.1%, and 30.7%, respectively) and medium-BED (67%, 28%, and 21%, 
      respectively) treated patients. Results are also discussed in terms of BED 
      calculated on alpha/beta 3 Gy characteristic of the microcapillary bed. No acute 
      toxicity higher than Grade 1 was observed. CONCLUSIONS: Radioablation of 
      pulmonary neoplastic nodules may be achieved with SRT delivered by using a 
      high-dose fraction with high BED value.
FAU - Casamassima, Franco
AU  - Casamassima F
AD  - Clinical Radiobiological Institute, University of Firenze, Firenze, Italy. 
      f.casamassima@dfc.unifi.it
FAU - Masi, Laura
AU  - Masi L
FAU - Bonucci, Ivano
AU  - Bonucci I
FAU - Polli, Caterina
AU  - Polli C
FAU - Menichelli, Claudia
AU  - Menichelli C
FAU - Gulisano, Massimo
AU  - Gulisano M
FAU - Pacini, Stefania
AU  - Pacini S
FAU - Aterini, Stefano
AU  - Aterini S
FAU - Cavedon, Carlo
AU  - Cavedon C
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20071231
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/mortality/pathology/*surgery
MH  - Dose Fractionation, Radiation
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung Neoplasms/diagnostic imaging/mortality/pathology/*surgery
MH  - Male
MH  - Radiography
MH  - *Radiosurgery
MH  - Relative Biological Effectiveness
MH  - Solitary Pulmonary Nodule/diagnostic imaging/mortality/pathology/*surgery
MH  - Survival Rate
MH  - Treatment Outcome
EDAT- 2008/01/01 09:00
MHDA- 2008/06/10 09:00
CRDT- 2008/01/01 09:00
PHST- 2007/03/30 00:00 [received]
PHST- 2007/09/17 00:00 [revised]
PHST- 2007/09/18 00:00 [accepted]
PHST- 2008/01/01 09:00 [pubmed]
PHST- 2008/06/10 09:00 [medline]
PHST- 2008/01/01 09:00 [entrez]
AID - S0360-3016(07)04246-0 [pii]
AID - 10.1016/j.ijrobp.2007.09.036 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):145-51. doi: 
      10.1016/j.ijrobp.2007.09.036. Epub 2007 Dec 31.