PMID- 18164902 OWN - NLM STAT- MEDLINE DCOM- 20080801 LR - 20210816 IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 100 IP - 1-3 DP - 2008 Mar TI - Analyses of variants located in estrogen metabolism genes (ESR1, ESR2, COMT and APOE) and schizophrenia. PG - 308-15 LID - 10.1016/j.schres.2007.11.001 [doi] AB - Relationships between gender, age-of-onset of schizophrenia and reproductive age strongly suggest a key role for gonadal hormones, and more specifically for estrogens, in the etiology of the illness. Also, estrogens act as neural growth and trophic factors influencing neuron and glial cells in many areas of the central nervous system. Therefore, we investigated the association between schizophrenia and 4 genes related to estrogen metabolism. These genes are ESR1 (estrogen receptor 1), ESR2 (estrogen receptor 2), APOE (apolipoprotein E) and COMT (catechol-O-methyltransferase). The expression of APOE and COMT, which contain estrogen response elements, have been demonstrated to be regulated by the estrogen receptors. In this current association study, we examined 59 single nucleotide polymorphisms (SNPs) located in the ESR1 (26), ESR2 (14), APOE (7) and COMT (12) loci. Allele frequencies were evaluated in the schizophrenia (n=585)-control (n=615) sample and no association was found with any of the four genes. In conclusion, our data suggest that the four analyzed genes do not play an important role in susceptibility to schizophrenia. FAU - Martorell, Lourdes AU - Martorell L AD - Hospital Psiquiatric Universitari Institut Pere Mata, Ctra. De l'Institut Pere Mata s/n, 43206 Reus, Spain. lourdes.martorell@urv.cat FAU - Costas, Javier AU - Costas J FAU - Valero, Joaquin AU - Valero J FAU - Gutierrez-Zotes, Alfonso AU - Gutierrez-Zotes A FAU - Phillips, Christopher AU - Phillips C FAU - Torres, Maria AU - Torres M FAU - Brunet, Anna AU - Brunet A FAU - Garrido, Gemma AU - Garrido G FAU - Carracedo, Angel AU - Carracedo A FAU - Guillamat, Roser AU - Guillamat R FAU - Valles, Vicenc AU - Valles V FAU - Guitart, Miriam AU - Guitart M FAU - Labad, Antonio AU - Labad A FAU - Vilella, Elisabet AU - Vilella E LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20071231 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 RN - 0 (Apolipoproteins E) RN - 0 (ESR1 protein, human) RN - 0 (Estrogen Receptor alpha) RN - 0 (Estrogen Receptor beta) RN - EC 2.1.1.6 (Catechol O-Methyltransferase) SB - IM MH - Apolipoproteins E/*genetics MH - Catechol O-Methyltransferase/*genetics MH - Chromosome Mapping/statistics & numerical data MH - Control Groups MH - Estrogen Receptor alpha/*genetics MH - Estrogen Receptor beta/*genetics MH - Female MH - Gene Frequency/genetics MH - Genetic Predisposition to Disease/genetics MH - Genetic Variation/*genetics MH - Genotype MH - Haplotypes/genetics MH - Humans MH - Linkage Disequilibrium/genetics MH - Male MH - Middle Aged MH - Polymorphism, Single Nucleotide/genetics MH - Risk Factors MH - Schizophrenia/*genetics MH - Sex Factors EDAT- 2008/01/01 09:00 MHDA- 2008/08/02 09:00 CRDT- 2008/01/01 09:00 PHST- 2007/06/04 00:00 [received] PHST- 2007/10/26 00:00 [revised] PHST- 2007/11/02 00:00 [accepted] PHST- 2008/01/01 09:00 [pubmed] PHST- 2008/08/02 09:00 [medline] PHST- 2008/01/01 09:00 [entrez] AID - S0920-9964(07)00507-5 [pii] AID - 10.1016/j.schres.2007.11.001 [doi] PST - ppublish SO - Schizophr Res. 2008 Mar;100(1-3):308-15. doi: 10.1016/j.schres.2007.11.001. Epub 2007 Dec 31.