PMID- 18164974
OWN - NLM
STAT- MEDLINE
DCOM- 20080312
LR  - 20220330
IS  - 0188-4409 (Print)
IS  - 0188-4409 (Linking)
VI  - 39
IP  - 2
DP  - 2008 Feb
TI  - Complex t(8;13;21)(q22;q14;q22)--a novel variant of t(8;21) in a patient with 
      acute myeloid leukemia (AML-M2).
PG  - 252-6
LID - 10.1016/j.arcmed.2007.09.002 [doi]
AB  - Variants of the t(8;21)(q22;q22) involving chromosome 8, 21, and other 
      chromosomes account for about 3% of all t(8;21)(q22;q22) in acute myeloid 
      leukemia (AML) patients. We report a case of AML-M2 with t(8;13;21)(q22;q14;q22), 
      not reported earlier. Using a dual-color fluorescence in situ hybridization 
      (FISH) analysis with ETO and AML1 probes, we demonstrate an ETO/AML1 fusion 
      signal on the derivative chromosome 8. Whole chromosome painting probes were used 
      for chromosomes 8 and 13, to demonstrate the three-way translocation 
      t(8;13;21)(q22;q14;q22). Involvement of chromosome region 13q14 has never been 
      reported earlier, although region 13q12 as a variant in AML with t(8;21) has been 
      reported earlier. The possible role of genes in this region in leukemogenesis, 
      its response to the treatment and its clinical implications are discussed.
FAU - Udayakumar, Achandira Muthappa
AU  - Udayakumar AM
AD  - Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos 
      University Hospital, Muscat, Sultanate of Oman. amuk19@hotmail.com
FAU - Alkindi, Salam
AU  - Alkindi S
FAU - Pathare, Anil Vasanth
AU  - Pathare AV
FAU - Raeburn, John Alexander
AU  - Raeburn JA
LA  - eng
PT  - Journal Article
DEP - 20071119
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RUNX1 Translocation Partner 1 Protein)
RN  - 0 (RUNX1 protein, human)
RN  - 0 (RUNX1T1 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 13/*genetics
MH  - Chromosomes, Human, Pair 21/*genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Core Binding Factor Alpha 2 Subunit/genetics
MH  - DNA-Binding Proteins/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics/pathology
MH  - Male
MH  - Oman
MH  - Oncogene Proteins, Fusion/genetics
MH  - Proto-Oncogene Proteins/genetics
MH  - RUNX1 Translocation Partner 1 Protein
MH  - Transcription Factors/genetics
MH  - *Translocation, Genetic
EDAT- 2008/01/01 09:00
MHDA- 2008/03/13 09:00
CRDT- 2008/01/01 09:00
PHST- 2007/05/16 00:00 [received]
PHST- 2007/07/31 00:00 [accepted]
PHST- 2008/01/01 09:00 [pubmed]
PHST- 2008/03/13 09:00 [medline]
PHST- 2008/01/01 09:00 [entrez]
AID - S0188-4409(07)00312-8 [pii]
AID - 10.1016/j.arcmed.2007.09.002 [doi]
PST - ppublish
SO  - Arch Med Res. 2008 Feb;39(2):252-6. doi: 10.1016/j.arcmed.2007.09.002. Epub 2007 
      Nov 19.