PMID- 18165909
OWN - NLM
STAT- MEDLINE
DCOM- 20080717
LR  - 20191210
IS  - 0962-9343 (Print)
IS  - 1573-2649 (Electronic)
IS  - 0962-9343 (Linking)
VI  - 17
IP  - 2
DP  - 2008 Mar
TI  - Validity, reliability, and responsiveness of the Kansas City Cardiomyopathy 
      Questionnaire in anemic heart failure patients.
PG  - 291-8
LID - 10.1007/s11136-007-9302-5 [doi]
AB  - BACKGROUND: While generic health status measures quantify the impact of all 
      patients' diseases on their health-related quality of life, disease specific 
      measures focus on only one of the many conditions that a patient may have. If a 
      patient has two diseases with similar clinical manifestations, they may respond 
      differently to a disease-specific instrument if one of their conditions improves 
      while the other worsens or remains stable, thus undermining the instruments in 
      that patient population. We sought empirical evidence of the reliability and 
      validity (including responsiveness) of the Kansas City Cardiomyopathy 
      Questionnaire (KCCQ), a disease-specific measure for heart failure (HF), among HF 
      patients with and without anemia, a condition that has similar symptoms to HF. 
      METHODS: This work used a prospective cohort study of 811 HF outpatients from 58 
      U.S. centers with a baseline assessment of anemia of whom 698 were followed for 3 
      months with serial health status measures. RESULTS: Among participants, 268 (33%) 
      were anemic. The construct validity of the KCCQ was supported by showing similar 
      correlations with the New York Heart Association (NYHA) classification in 
      patients with and without anemia (P value for interaction = 0.38). The internal 
      consistency (Cronbach's alpha = 0.92 and 0.93 for anemic and non-anemic patients, 
      respectively) and test-retest reliability (mean 3-month change scores in stable 
      patients = -2.8 [SD = 1.4] and -0.5 [SD = 0.8], P = 0.14) were similar. Estimates 
      of responsiveness were also similar. CONCLUSION: This study provides empirical 
      evidence that the psychometric properties of the KCCQ are similar in patients 
      with or without anemia, a potentially confounding clinical condition in patients 
      with heart failure.
FAU - Spertus, John A
AU  - Spertus JA
AD  - Mid America Heart Institute, 4401 Wornall Road, Kansas City, MO 64111, USA. 
      spertusj@umkc.edu
FAU - Jones, Philip G
AU  - Jones PG
FAU - Kim, John
AU  - Kim J
FAU - Globe, Denise
AU  - Globe D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20071229
PL  - Netherlands
TA  - Qual Life Res
JT  - Quality of life research : an international journal of quality of life aspects of 
      treatment, care and rehabilitation
JID - 9210257
SB  - IM
MH  - Aged
MH  - Anemia/*complications
MH  - Cardiomyopathies
MH  - Female
MH  - *Health Status Indicators
MH  - Heart Failure/*complications
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Patient Participation
MH  - Prospective Studies
MH  - Psychometrics
MH  - *Quality of Life
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - *Surveys and Questionnaires
PMC - PMC2238779
EDAT- 2008/01/01 09:00
MHDA- 2008/07/18 09:00
PMCR- 2008/02/12
CRDT- 2008/01/01 09:00
PHST- 2007/01/16 00:00 [received]
PHST- 2007/12/09 00:00 [accepted]
PHST- 2008/01/01 09:00 [pubmed]
PHST- 2008/07/18 09:00 [medline]
PHST- 2008/01/01 09:00 [entrez]
PHST- 2008/02/12 00:00 [pmc-release]
AID - 9302 [pii]
AID - 10.1007/s11136-007-9302-5 [doi]
PST - ppublish
SO  - Qual Life Res. 2008 Mar;17(2):291-8. doi: 10.1007/s11136-007-9302-5. Epub 2007 
      Dec 29.