PMID- 18165925
OWN - NLM
STAT- MEDLINE
DCOM- 20080618
LR  - 20211203
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 311
IP  - 1-2
DP  - 2008 Apr
TI  - ACE I/D polymorphism in Indian patients with hypertrophic cardiomyopathy and 
      dilated cardiomyopathy.
PG  - 67-72
LID - 10.1007/s11010-007-9695-z [doi]
AB  - AIM: The study was carried to determine the association of angiotensin converting 
      enzyme (ACE) insertion/deletion (I/D) polymorphism with the risk of hypertrophic 
      cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and restrictive 
      cardiomyopathy (RCM). METHODS AND RESULTS: A total of 174 patients diagnosed with 
      cardiomyopathy (118 with HCM, 51 with DCM, and 5 with RCM) and 164 ethnically, 
      age- and gender-matched controls were included in the study. ACE I/D genotyping 
      was performed by PCR. In total, 25.86% of the patients were in New York Heart 
      Association (NYHA) class III and IV at presentation. A total of 67.24% patients 
      had dyspnea, 56.89% had angina pectoris, and 25.28% of the patients had at least 
      one event of syncope. Frequency of occurrence of the disease was more in male 
      patients compared to female patients (P < 0.05). After adjustment for age, sex, 
      body mass index (BMI), and smoking habit, the prevalence of ACE DD genotype, and 
      ACE 'D' allele was significantly higher in patients as compared to controls and 
      was associated with increased risk (DD: OR 2.11, 95% CI 1.27-3.52, P < 0.05; 'D': 
      OR 1.91, 95% CI 1.08-3.35, P < 0.05). The mean septal thickness was higher for DD 
      and ID genotypes (20.40 +/- 3.73 mm and 21.82 +/- 5.35 mm, respectively) when 
      compared with II genotype (18.63 +/- 6.69 mm) in HCM patients, however, the 
      differences were not significant statistically (P > 0.05). The DCM patients with 
      ID genotype showed significantly decreased left ventricular ejection fraction 
      (LVEF) at enrolment (26.50 +/- 8.04%) (P = 0.04). CONCLUSION: Our results suggest 
      that D allele of ACE I/D polymorphism significantly influences the HCM and DCM 
      phenotypes.
FAU - Rai, Taranjit Singh
AU  - Rai TS
AD  - Department of Experimental Medicine and Biotechnology, Post Graduate Institute of 
      Medical Education and Research, Chandigarh 160012, India.
FAU - Dhandapany, Perundurai Subramaniam
AU  - Dhandapany PS
FAU - Ahluwalia, Tarunveer Singh
AU  - Ahluwalia TS
FAU - Bhardwaj, Monica
AU  - Bhardwaj M
FAU - Bahl, Ajay
AU  - Bahl A
FAU - Talwar, Kewal Krishan
AU  - Talwar KK
FAU - Nair, Krishnakumar
AU  - Nair K
FAU - Rathinavel, Andiappan
AU  - Rathinavel A
FAU - Khullar, Madhu
AU  - Khullar M
LA  - eng
PT  - Journal Article
DEP - 20071230
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - EC 3.4.23.15 (Renin)
SB  - IM
MH  - Adult
MH  - Cardiomyopathies/diagnosis/*enzymology/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - India
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - *Racial Groups/genetics
MH  - Renin/*genetics
MH  - Risk Factors
EDAT- 2008/01/01 09:00
MHDA- 2008/06/19 09:00
CRDT- 2008/01/01 09:00
PHST- 2007/10/15 00:00 [received]
PHST- 2007/12/17 00:00 [accepted]
PHST- 2008/01/01 09:00 [pubmed]
PHST- 2008/06/19 09:00 [medline]
PHST- 2008/01/01 09:00 [entrez]
AID - 10.1007/s11010-007-9695-z [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2008 Apr;311(1-2):67-72. doi: 10.1007/s11010-007-9695-z. Epub 
      2007 Dec 30.