PMID- 18166187
OWN - NLM
STAT- MEDLINE
DCOM- 20081114
LR  - 20081020
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 90
IP  - 4
DP  - 2008 Oct
TI  - Study of aneuploidy in large-headed, multiple-tailed spermatozoa: case report and 
      review of the literature.
PG  - 1201.e13-7
LID - 10.1016/j.fertnstert.2007.09.013 [doi]
AB  - OBJECTIVE: To determine the meiotic segregation in large-headed, multiple-tailed 
      spermatozoa. DESIGN: Analysis of sperm nuclei by fluorescence in situ 
      hybridization (FISH). SETTING: University hospital. PATIENT(S): A 34-year-old man 
      with 100% morphologically abnormal spermatozoa. INTERVENTION(S): Dual-color FISH 
      for chromosomes 13 and 21 and triple-color FISH for chromosomes X, Y, and 18 were 
      performed. MAIN OUTCOME MEASURE(S): Aneuploidy rates. RESULT(S): More than 99% of 
      the spermatozoa had abnormal content for chromosomes X, Y, 13, 18, and 21. 
      Diploidy, triploidy, and tetraploidy rates were found to be 18.42%, 6.14%, and 
      33.99% in triple-color FISH and to be 16.09%, 16.28%, and 38.95% in dual-color 
      FISH. CONCLUSION(S): Our results and those from other investigators show that 
      large-headed, multiple-tailed spermatozoa are associated with a high rate of 
      polyploidy and aneuploidy. Intracytoplasmic sperm injection should not be 
      recommended to those patients, not only because of its low success rate but also 
      because of its high genetic risk.
FAU - Perrin, Aurore
AU  - Perrin A
AD  - Faculte de Medecine et des Sciences de la Sante, Laboratoire d'Histologie, 
      Embryologie et Cytogenetique, Universite de Bretagne Occidentale, Brest, France.
FAU - Morel, Frederic
AU  - Morel F
FAU - Moy, Ludovic
AU  - Moy L
FAU - Colleu, Daniel
AU  - Colleu D
FAU - Amice, Veronique
AU  - Amice V
FAU - De Braekeleer, Marc
AU  - De Braekeleer M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071231
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - *Aneuploidy
MH  - Azoospermia/*genetics/*pathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oligospermia/diagnosis/*genetics/*pathology
MH  - Sperm Head/*pathology
MH  - Sperm Tail/*pathology
RF  - 46
EDAT- 2008/01/02 09:00
MHDA- 2008/11/15 09:00
CRDT- 2008/01/02 09:00
PHST- 2007/06/28 00:00 [received]
PHST- 2007/09/10 00:00 [revised]
PHST- 2007/09/10 00:00 [accepted]
PHST- 2008/01/02 09:00 [pubmed]
PHST- 2008/11/15 09:00 [medline]
PHST- 2008/01/02 09:00 [entrez]
AID - S0015-0282(07)03557-1 [pii]
AID - 10.1016/j.fertnstert.2007.09.013 [doi]
PST - ppublish
SO  - Fertil Steril. 2008 Oct;90(4):1201.e13-7. doi: 10.1016/j.fertnstert.2007.09.013. 
      Epub 2007 Dec 31.