PMID- 18167042
OWN - NLM
STAT- MEDLINE
DCOM- 20080729
LR  - 20131121
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 22
IP  - 4
DP  - 2008 Apr
TI  - Inhibitory effect of Ginkgo biloba extract on hyperhomocysteinemia-induced 
      intimal thickening in rabbit abdominal aorta after balloon injury.
PG  - 506-10
LID - 10.1002/ptr.2353 [doi]
AB  - Ginkgo biloba extract (GBE) has been widely used to treat cardiovascular and 
      cerebrovascular disorders. Hyperhomocysteinemia (Hhcy) is associated with the 
      risk of atherosclerosis and restenosis after angioplasty. The objective of this 
      study was to investigate whether GBE could attenuate the Hhcy-induced intimal 
      thickening after balloon injury in rabbit abdominal aorta. It was observed in 
      this study that GBE could decrease the neointima area (NA) and the ratio of the 
      neointima area to the media area (NA/MA), down-regulate the mRNA expression of 
      matrix metalloproteinase-9 (MMP-9) and up-regulate the protein expression of p21 
      (WAF1/CIP1) (p21). It suggests that GBE can reverse the Hhcy-induced neointima 
      formation in rabbits following balloon injury, and the suppressive effect of GBE 
      on the migration and proliferation of vascular smooth muscle cells (VSMCs) may 
      contribute to its actions.
CI  - (c) 2007 John Wiley & Sons, Ltd.
FAU - Liu, Fenye
AU  - Liu F
AD  - Department of Traditional Chinese Medicine, Qilu Hospital Affiliated to Shandong 
      University, Jinan 250012, Shandong, PR China.
FAU - Zhang, Jidong
AU  - Zhang J
FAU - Yu, Shudong
AU  - Yu S
FAU - Wang, Rong
AU  - Wang R
FAU - Wang, Bo
AU  - Wang B
FAU - Lai, Liping
AU  - Lai L
FAU - Yin, Huiqiu
AU  - Yin H
FAU - Liu, Guilin
AU  - Liu G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Aorta, Abdominal/*drug effects/injuries
MH  - Blotting, Western
MH  - Catheterization/adverse effects
MH  - Cyclin-Dependent Kinase Inhibitor p21/metabolism
MH  - Ginkgo biloba/*chemistry
MH  - Homocysteine/blood
MH  - Hyperhomocysteinemia/*complications
MH  - Male
MH  - Matrix Metalloproteinase 9/genetics
MH  - Plant Extracts/chemistry/*pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rabbits
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tunica Intima/*drug effects/pathology
MH  - Vascular Diseases/blood/etiology/prevention & control
EDAT- 2008/01/02 09:00
MHDA- 2008/07/30 09:00
CRDT- 2008/01/02 09:00
PHST- 2008/01/02 09:00 [pubmed]
PHST- 2008/07/30 09:00 [medline]
PHST- 2008/01/02 09:00 [entrez]
AID - 10.1002/ptr.2353 [doi]
PST - ppublish
SO  - Phytother Res. 2008 Apr;22(4):506-10. doi: 10.1002/ptr.2353.