PMID- 18167054
OWN - NLM
STAT- MEDLINE
DCOM- 20080624
LR  - 20080205
IS  - 0951-418X (Print)
IS  - 0951-418X (Linking)
VI  - 22
IP  - 2
DP  - 2008 Feb
TI  - Phlomis umbrosa root inhibits mast cell-dependent allergic reactions and 
      inflammatory cytokine secretion.
PG  - 153-8
LID - 10.1002/ptr.2164 [doi]
AB  - The effect of an aqueous extract of Phlomis umbrosa Turcz. (Labiatae) root (PUAE) 
      on mast cell-dependent allergic reactions and inflammatory cytokine secretion 
      were investigated. PUAE (0.01-1 g/kg) inhibited compound 48/80-induced systemic 
      allergic reaction. When PUAE was employed in a systemic allergic reaction test, 
      the plasma histamine levels were reduced in a dose-dependent manner. PUAE (0.1 
      and 1 g/kg) also significantly inhibited the local allergic reaction activated by 
      anti-dinitrophenyl (DNP) IgE. PUAE (0.001-1 mg/mL) dose-dependently inhibited the 
      histamine release from rat peritoneal mast cells activated by compound 48/80 or 
      anti-DNP IgE. PUAE (0.01-1 mg/mL) inhibited the secretion of interleukin 
      (IL)-1beta in phorbol 12-myristate 13-acetate plus calcium ionophore 
      A23187-stimulated human mast cell line (HMC-1) cells. PUAE (1 mg/mL) inhibited 
      the gene expression and production of the main inflammatory cytokine, TNF-alpha, 
      in HMC-1 cells. These results provide evidence that PUAE may be beneficial in the 
      treatment of allergic diseases.
FAU - Shin, Tae-Yong
AU  - Shin TY
AD  - College of Pharmacy, Woosuk University, Jeonju, Jeonbuk 565-701, Republic of 
      Korea. tyshin@mail.woosuk.ac.kr
FAU - Kim, Sang-Hyun
AU  - Kim SH
FAU - Kim, Dae-Keun
AU  - Kim DK
FAU - Leem, Kang-Hyun
AU  - Leem KH
FAU - Park, Jeong-Suk
AU  - Park JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Cell Line
MH  - Cytokines/genetics/*metabolism
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Gene Expression/drug effects
MH  - Histamine Release/drug effects
MH  - Humans
MH  - Hypersensitivity/immunology/*prevention & control
MH  - Inflammation Mediators/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Male
MH  - Mast Cells/*drug effects/metabolism/pathology
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Phlomis/*chemistry
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Plant Roots/*chemistry
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tumor Necrosis Factor-alpha/genetics/metabolism
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2008/01/02 09:00
MHDA- 2008/06/25 09:00
CRDT- 2008/01/02 09:00
PHST- 2008/01/02 09:00 [pubmed]
PHST- 2008/06/25 09:00 [medline]
PHST- 2008/01/02 09:00 [entrez]
AID - 10.1002/ptr.2164 [doi]
PST - ppublish
SO  - Phytother Res. 2008 Feb;22(2):153-8. doi: 10.1002/ptr.2164.