PMID- 18172660
OWN - NLM
STAT- MEDLINE
DCOM- 20080826
LR  - 20181113
IS  - 0937-4477 (Print)
IS  - 0937-4477 (Linking)
VI  - 265
IP  - 5
DP  - 2008 May
TI  - Travelling wave velocity test and Meniere's disease revisited.
PG  - 517-23
LID - 10.1007/s00405-007-0486-7 [doi]
AB  - Transtympanic Electrocochleography (TT-ECoG) and the glycerol test can aid in the 
      diagnostic process of Meniere's disease (MD). Measurement of travelling wave 
      velocity (TWV) has been proposed as an alternative to TT-ECoG to detect 
      endolymphatic hydrops. We assessed the feasibility and obtained normative data of 
      the TWV test in the diagnosis of MD, and compared the test results in MD patients 
      with their symptoms and their TT-ECoG results. The TWV test records two runs of 
      auditory brainstem responses to clicks that are ipsilaterally masked with two 
      different high pass filtered noise bands. The resulting latency difference of 
      peak V was used as a measure of the TWV. The 95% confidence interval of this 
      latency difference was defined in a group of 28 normals. Subsequently, the test 
      was performed in nine MD patients. After the TWV test, seven of these patients 
      underwent a TT-ECoG. The symptoms of MD patients at the time of testing and their 
      TT-ECoG results were compared with TWV test results. The 95% confidence interval 
      of the latency difference of peak V in the control group was 0.190-0.668 ms. A 
      latency difference <0.190 ms indicates an increase in TWV, and thus reflects a 
      positive test. In nine MD patients, we found a clear correlation between the 
      result of the TWV test and TT-ECoG. The TWV test result did not significantly 
      correlate with a single symptom. Our findings suggest that the TWV test can be 
      useful to detect endolymphatic hydrops, but further experiments with larger 
      patient groups are needed to confirm the diagnostic value of the TWV test.
FAU - Claes, Gerd M E
AU  - Claes GM
AD  - University of Antwerp, University Hospital of Antwerp, ENT Department, 
      Wilrijkstraat 10, 2650 Edegem, Belgium. gerdclaes@yahoo.com
FAU - Wyndaele, Michel
AU  - Wyndaele M
FAU - De Valck, Claudia F J
AU  - De Valck CF
FAU - Claes, Jos
AU  - Claes J
FAU - Govaerts, Paul
AU  - Govaerts P
FAU - Wuyts, Floris L
AU  - Wuyts FL
FAU - Van de Heyning, Paul H
AU  - Van de Heyning PH
LA  - eng
PT  - Journal Article
DEP - 20080103
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Adult
MH  - Audiometry, Evoked Response/*methods
MH  - Audiometry, Pure-Tone
MH  - Endolymphatic Hydrops/*diagnosis/physiopathology
MH  - Evoked Potentials, Auditory, Brain Stem/*physiology
MH  - Feasibility Studies
MH  - Female
MH  - Humans
MH  - Male
MH  - Meniere Disease/*diagnosis/physiopathology
EDAT- 2008/01/04 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/01/04 09:00
PHST- 2007/08/27 00:00 [received]
PHST- 2007/09/28 00:00 [accepted]
PHST- 2008/01/04 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/01/04 09:00 [entrez]
AID - 10.1007/s00405-007-0486-7 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2008 May;265(5):517-23. doi: 
      10.1007/s00405-007-0486-7. Epub 2008 Jan 3.